ArticleNature communications2022
Crystal structure and functional implication of bacterial STING.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- A unique Z-shaped tetramer mediates the autoinhibition of waterfowl STING.PLoS pathogens · 2026Article
- Characterization of the binding features between SARS-CoV-2 5'-proximal transcripts of genomic RNA and nucleocapsid proteins.RNA biology · 2025Review
- Article
- A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunity.bioRxiv : the preprint server for biology · 2025Article
- Evolutionarily ancient functions of enzymatic TIR proteins in innate immunity.Trends in immunology · 2025Review
- A central role of stimulator of interferon genes' adaptor protein in defensive immune response.Immunologic research · 2025Review
- Advances in the prerequisite and consequence of STING downstream signalosomes.Medical review (2021) · 2024Review
- Structural and functional characterization of cyclic pyrimidine-regulated anti-phage system.Nature communications · 2024Article
- Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.Molecular cell · 2024Article
- cGAS goes viral: A conserved immune defense system from bacteria to humans.Molecular cell · 2024Review
- Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects.Journal of inflammation research · 2024Review
- STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulatingJournal of biosciences · 2024Article
- Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING.Nature communications · 2023Article
- CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling.Annual review of virology · 2023Review
- Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases.Nature communications · 2023Article
- Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.bioRxiv : the preprint server for biology · 2023Article
- The Many Ways to Deal with STING.International journal of molecular sciences · 2023Review
- Bacteriophage strategies for overcoming host antiviral immunity.Frontiers in microbiology · 2023Review
- The arms race between bacteria CBASS and bacteriophages.Frontiers in immunology · 2023Review
- Bacterial origins of cyclic nucleotide-activated antiviral immune signaling.Molecular cell · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian innate immune sensor STING (STimulator of INterferon Gene) was recently found to originate from bacteria. During phage infection, bacterial STING sense c-di-GMP generated by the CD-NTase (cGAS/DncV-like nucleotidyltransferase) encoded in the same operon and signal suicide commitment as a defense strategy that restricts phage propagation. However, the precise binding mode of c-di-GMP to bacterial STING and the specific recognition mechanism are still elusive. Here, we determine two complex crystal structures of bacterial STING/c-di-GMP, which provide a clear picture of how c-di-GMP is distinguished from other cyclic dinucleotides. The protein-protein interactions further reveal the driving force behind filament formation of bacterial STING. Finally, we group the bacterial STING into two classes based on the conserved motif in β-strand lid, which dictate their ligand specificity and oligomerization mechanism, and propose an evolution-based model that describes the transition from c-di-GMP-dependent signaling in bacteria to 2'3'-cGAMP-dependent signaling in eukaryotes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.