Observational studyMenopause (New York, N.Y.)2022
Association of sleep disturbance with Parkinson disease: evidence from the Women's Health Initiative.
Observational study in Menopause (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Menopause and neurological disorders: a roadmap for research.Nature reviews. Neurology · 2026Review
- Sleep Duration, Chronotype, and Mortality in Parkinson's Disease: A Prospective Cohort Study.Nature and science of sleep · 2026Article
- Insomnia, sleep duration and incident Parkinson's disease in the Finnish population cohort.Brain communications · 2026Article
- Psychiatric disorders among older U.S. women by socioeconomic and veteran status.Journal of affective disorders · 2025Article
- Self-perceived life course sleep duration trajectories and risk and age at onset of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Article
- Reducing Parkinson's disease incidence in patients with insomnia through acupuncture: A cohort study.Integrative medicine research · 2024Article
- Association of accelerometer-measured physical activity and incident Parkinson's disease: insights and future research directions.NPJ digital medicine · 2024Article
- Physical activity and sleep pattern in relation to incident Parkinson's disease: a cohort study.The international journal of behavioral nutrition and physical activity · 2024Article
- Association Between Sleep Characteristics and Likelihood of Prodromal Parkinson's Disease: A Cross-Sectional Analysis in the HABIT Study.Nature and science of sleep · 2024Article
- Sleep and affective disorders in relation to Parkinson's disease risk among older women from the Women's Health Initiative.Journal of affective disorders · 2022Observational
- State-of-the-art review of the clinical research on menopause and hormone replacement therapy association with Parkinson's disease: What meta-analysis studies cannot tell us.Frontiers in aging neuroscience · 2022Review
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association of sleep disturbance with Parkinson disease (PD) during 10+ years of follow-up among postmenopausal women, 50 to 79 years of age at baseline.
methodsLongitudinal data on 130,502 study-eligible women (mean ± standard deviation baseline age = 63.16 ± 7.20 y) from the Women's Health Initiative Clinical Trials and Women's Health Initiative Observational Study were analyzed. The cohort was followed for 15.88 ± 6.50 years, yielding 2,829 (2.17%) PD cases. Sleep disturbance (habitual sleep duration, insomnia symptoms, obstructive sleep apnea risk factors, sleep aids among those with WHI Insomnia Rating Scale scores (WHIIRS) > 9) was measured at baseline and one follow-up time by September 12, 2005. Cox proportional hazards models evaluated relationships controlling for sociodemographic, lifestyle, and health characteristics.
resultsPD was significantly associated with long sleep duration (≥9 h) versus a benchmark of 7 to 8 hours (hazard ratio [HR] = 1.296, 95% confidence interval [CI]: 1.153-1.456), WHIIRS (>9 vs ≤9) (HR = 1.114, 95% CI:1.023-1.214), and use of sleep aids (yes vs no) (HR = 1.332, 95% CI:1.153-1.539) among those with WHIIRS > 9. Compared with 7 to 8 hours, short (<7 h) sleep duration was unrelated to PD. Finally, the presence of obstructive sleep apnea risk factors was not associated with PD.
conclusionsAmong postmenopausal women, sleep disturbance was associated with approximately 10% to 30% increased PD risk after ∼16 years follow-up. Prospective cohort studies with objective exposures and adjudicated outcomes that include men and women of diverse backgrounds are required to confirm and extend these findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.