ArticleJournal of atherosclerosis and thrombosis2022
Association between Achilles Tendon Softness and Atherosclerotic Cardiovascular Disease in Patients with Familial Hypercholesterolemia.
Article in Journal of atherosclerosis and thrombosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
- Association between Achilles tendon abnormalities and systemic atherosclerosis in patients undergoing percutaneous coronary intervention.International journal of cardiology. Heart & vasculature · 2026Article
- Association of Achilles Tendon Thickness with Severity of Coronary Artery Disease in Non -Familial Hypercholesterolemia.Journal of atherosclerosis and thrombosis · 2026Article
- Discordance in diagnostic assessment of Achilles tendon thickening between soft X-ray radiography and ultrasonography among patients with coronary artery disease.Scientific reports · 2026Article
- Discordance in Achilles Tendon Assessment between Radiography and Ultrasonography due to Torsion.Journal of atherosclerosis and thrombosis · 2026Article
- Clinical Impact of Familial Hypercholesterolemia on Lower Extremity Artery Disease in Premature Patients.Annals of vascular diseases · 2026Article
- Clinical Impact of Lipoprotein (a) and Cumulative Low-Density Lipoprotein Cholesterol Exposure on Coronary Artery Disease in Patients with Heterozygous Familial Hypercholesterolemia.Journal of atherosclerosis and thrombosis · 2025Article
- Risk Assessment for Cardiovascular Events using Achilles Tendon Thickness and Softness and Intima-Media Thickness in Familial Hypercholesterolemia.Journal of atherosclerosis and thrombosis · 2024Article
- Review
- International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia.Nature reviews. Cardiology · 2023Review
- Patients with Achilles Tendon Rupture Are Prone to Develop Ventricular Arrhythmia.Journal of clinical medicine · 2023Article
- Hypoxia inducible factor-1α mediates the mechanism of the Hedgehog pathway in tendinopathy repair by Asperosaponin VI.Regenerative therapy · 2022Review
- Can Achilles Tendon Assessment of Adult Familial Hypercholesterolemia be Reflected as a Risk Factor for Arteriosclerosis?Journal of atherosclerosis and thrombosis · 2022Article
- Diabetes and Familial Hypercholesterolemia: Interplay between Lipid and Glucose Metabolism.Nutrients · 2022Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAchilles tendon (AT) xanthomas are a specific physical finding of familial hypercholesterolemia (FH) and AT thickness has been used for its diagnosis and evaluation of its severity. Recently, we reported that the AT of FH patients was softer than that of non-FH patients and the combined use of a cut-off value for AT softness with that for AT thickness improved diagnostic accuracy. However, an association between AT softness and severity of atherosclerosis has not been reported. Accordingly, the present study aimed to investigate whether AT softness was associated with carotid atherosclerosis and presence of atherosclerotic cardiovascular disease (ASCVD) in FH.
methodsThe AT of 176 genetically diagnosed FH patients and 98 non-FH patients was examined to measure AT thickness and the elasticity index (EI) as an indicator for assessing AT softness using ultrasonography.
resultsIncreased age was associated with AT softness, and overweight was negatively related to AT softness. There were significant inverse correlations between EI and maximum and mean intima-media thickness (IMT) within the common carotid artery only among FH patients. In multiple linear regression analysis, although the relationship between EI and mean IMT was attenuated, the association between EI and maximum IMT remained robust. In logistic regression analysis adjusted for age, sex and traditional cardiovascular risk factors (smoking history, presence of hypertension, presence of diabetes mellitus, overweight, LDL-cholesterol, HDL-cholesterol, and Log triglycerides), EI was associated with presence of ASCVD (Odds ratio per 1-SD increase, 0.37; 95% CI, 0.15 - 0.86; P=0.0252).
conclusionThe degree of lipid deposition in the AT of FH patients could be assessed by its thickness as well as its softness. AT softness is not only useful in diagnosing FH but is also associated with the severity of carotid atherosclerosis and presence of ASCVD. In addition, these findings suggest that AT softness would be helpful in risk assessment for FH patients.
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