Evidence map›Paper›PMID 35013005›Full record

ArticleAging2022

Multivariate patterns of brain-behavior associations across the adult lifespan.

Gaelle E Doucet, Noah Hamlin, Anna West, Jordanna A Kruse, Dominik A Moser, Tony W Wilson

Abstract read
In one paragraph

Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gaelle E DoucetInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
Noah HamlinInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
Anna WestInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
Jordanna A KruseInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
Dominik A MoserInstitute of Psychology, University of Bern, Bern, Switzerland.
Tony W WilsonInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.

Funding

MULTIMODAL IMAGING OF NEUROHIV DYNAMICS (MIND): AN OMAHA-PITTSBURGH CONSORTIUMR01MH118013 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2018 to 2022
$4.9M
SIGNATURES OF CANNABIS ABUSE IN NEUROHIV (SCAN): AN INTEGRATED MOLECULAR AND IMAGING APPROACHR01DA047828 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BECKER, JAMES T., FOX, HOWARD S · 2018 to 2022
$4.5M
THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECTR01MH116782 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2018 to 2022
$3.4M
THE IMPACT OF SPONTANEOUS CORTICAL ACTIVITY ON NEURAL OSCILLATIONS AND BEHAVIORAL PERFORMANCE: EVIDENCE FROM HIGH-DEFINITION TDCS AND MEGRF1MH117032 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2018 to 2018
$2.4M
Atlas55+: Creation and Validation of a Reference Brain Functional Atlas for Late AdulthoodR03AG064001 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DOUCET, GAELLE EVE · 2019 to 2020
$162k
NIA NIH HHS R03 AG064001NIDA NIH HHS R01 DA047828NIMH NIH HHS R01 MH116782NIMH NIH HHS R01 MH118013NIMH NIH HHS RF1 MH117032
6 · The paper itself

Abstract

The nature of brain-behavior covariations with increasing age is poorly understood. In the current study, we used a multivariate approach to investigate the covariation between behavioral-health variables and brain features across adulthood. We recruited healthy adults aged 20-73 years-old (29 younger, mean age = 25.6 years; 30 older, mean age = 62.5 years), and collected structural and functional MRI (s/fMRI) during a resting-state and three tasks. From the sMRI, we extracted cortical thickness and subcortical volumes; from the fMRI, we extracted activation peaks and functional network connectivity (FNC) for each task. We conducted canonical correlation analyses between behavioral-health variables and the sMRI, or the fMRI variables, across all participants. We found significant covariations for both types of neuroimaging phenotypes (

Indexed as

AdultAgedAgingBehaviorBrainBrain MappingCanonical Correlation AnalysisCognitionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetYoung Adultbrain networkshealthy aginghigher-order cognitionMRImultivariate analyses

Identifiers

PMID35013005
PMCPMC8791210

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.