ArticleProceedings of the National Academy of Sciences of the United States of America2022
Early antitumor activity of oral Langerhans cells is compromised by a carcinogen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Imbalanced p53-RB signaling triggers cGAS-STING-mediated immune activation in early oral cancer development.Oncogene · 2026Article
- An oral lichen planus-like mouse model driven by IFN-γ signaling and cytotoxic CD8+ T cells.JCI insight · 2026Article
- Dendritic cells: the central partner for cancer immunity.Oncoimmunology · 2025Review
- Longitudinal Imaging of the Premalignant Tumor Microenvironment Reveals Transient Myeloid States Predictive of Tumor Fate.bioRxiv : the preprint server for biology · 2025Article
- The role of the epithelial sentinels, Langerhans cells and γδT cells, in oral squamous cell carcinoma.Periodontology 2000 · 2024Review
- The roles of tissue resident macrophages in health and cancer.Experimental hematology & oncology · 2024Review
- IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells.International journal of biological sciences · 2024Article
- New insights into the role of the oral leukoplakia microenvironment in malignant transformation.Frontiers in oral health · 2024Review
- Unravelling monocyte functions: from the guardians of health to the regulators of disease.Discovery immunology · 2024Review
- Deciphering tumor-infiltrating dendritic cells in the single-cell era.Experimental hematology & oncology · 2023Review
- Langerhans cells shape postnatal oral homeostasis in a mechanical-force-dependent but microbiota and IL17-independent manner.Nature communications · 2023Article
- Tissue-specific macrophages: how they develop and choreograph tissue biology.Nature reviews. Immunology · 2023Review
- Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis.EMBO molecular medicine · 2022Article
- Article
- Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone.Frontiers in surgery · 2022Article
- Single-cell analysis of myeloid cells in HPVFrontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early diagnosis of oral squamous cell carcinoma (OSCC) remains an unmet clinical need. Therefore, elucidating the initial events of OSCC preceding tumor development could benefit OSCC prognosis. Here, we define the Langerhans cells (LCs) of the tongue and demonstrate that LCs protect the epithelium from carcinogen-induced OSCC by rapidly priming αβT cells capable of eliminating γH2AX
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.