Evidence map›Paper›PMID 35012976›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Heterologous vaccination interventions to reduce pandemic morbidity and mortality: Modeling the US winter 2020 COVID-19 wave.

Nathaniel Hupert, Daniela Marín-Hernández, Bo Gao, Ricardo Águas, Douglas F Nixon

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
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  9. Review
  10. COVID-19 Vaccine Hesitancy in South Africa: Lessons for Future Pandemics.International journal of environmental research and public health · 2022
    Article
  11. Understanding Kids and COVID.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Trained Immunity and HIV Infection.Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nathaniel HupertDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY 10065; nah2005@med.cornell.edu.ORCID https://orcid.org/0000-0002-7590-3680
Daniela Marín-HernándezDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065.ORCID https://orcid.org/0000-0003-1362-6881
Bo GaoCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.ORCID https://orcid.org/0000-0002-7405-7507
Ricardo ÁguasCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.ORCID https://orcid.org/0000-0002-6507-6597
Douglas F NixonDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065.ORCID https://orcid.org/0000-0002-2801-1786
Cornell University · USUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 remains a stark health threat worldwide, in part because of minimal levels of targeted vaccination outside high-income countries and highly transmissible variants causing infection in vaccinated individuals. Decades of theoretical and experimental data suggest that nonspecific effects of non-COVID-19 vaccines may help bolster population immunological resilience to new pathogens. These routine vaccinations can stimulate heterologous cross-protective effects, which modulate nontargeted infections. For example, immunization with

Indexed as

Models, TheoreticalSeasonsAlgorithmsBCG VaccineCOVID-19COVID-19 VaccinesHospitalizationHospital MortalityHumansIntensive Care UnitsPandemicsPatient AdmissionSARS-CoV-2Survival RateUnited StatesVaccinationBCG VaccineCOVID-19 VaccinesBCGCOVID-19infectious disease modelingtrained immunityvaccination

Identifiers

PMID35012976
PMCPMC8784160
OpenAlexW4206204866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.