Evidence map›Paper›PMID 35012844›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2022

Dorsal visual stream is preferentially engaged during externally guided action selection in Parkinson Disease.

Hiro Sparks, Katy A Cross, Jeong Woo Choi, Hristos Courellis, Jasmine Thum, Emily Koenig, Nader Pouratian

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hiro SparksDepartment of Neurosurgery, 300 UCLA Stein Plaza, Suite 562, David Geffen School of Medicine at UCLA (University of California, Los Angeles), Los Angeles, CA, USA.
Katy A CrossDepartment of Neurology, 710 Westwood Plaza, David Geffen School of Medicine at UCLA (University of California, Los Angeles), Los Angeles, CA, USA.
Jeong Woo ChoiDepartment of Neurological Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd MC 8855, Dallas, TX, USA.
Hristos CourellisDepartment of Neurosurgery, 300 UCLA Stein Plaza, Suite 562, David Geffen School of Medicine at UCLA (University of California, Los Angeles), Los Angeles, CA, USA.
Jasmine ThumDepartment of Neurosurgery, 300 UCLA Stein Plaza, Suite 562, David Geffen School of Medicine at UCLA (University of California, Los Angeles), Los Angeles, CA, USA.
Emily KoenigDepartment of Neurological Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd MC 8855, Dallas, TX, USA.
Nader PouratianDepartment of Neurological Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd MC 8855, Dallas, TX, USA. Electronic address: nader.pouratian@utsouthwestern.edu.
University of California, Los Angeles · USThe University of Texas Southwestern Medical Center · USNeurological Surgery · US

Funding

The Pathophysiology of Network Synchrony in Parkinson's DiseaseR01NS097782 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI NADER POURATIAN · 2016 to 2026
$5.2M
NINDS NIH HHS R01 NS097782
6 · The paper itself

Abstract

objectiveIn patients with Parkinson Disease (PD), self-initiated or internally cued (IC) actions are thought to be compromised by the disease process, as exemplified by impairments in action initiation. In contrast, externally-cued (EC) actions which are made in response to sensory prompts can restore a remarkable degree of movement capability in PD, particularly alleviating freezing-of-gait. This study investigates the electrophysiological underpinnings of movement facilitation in PD through visuospatial cuing, with particular attention to the dynamics within the posterior parietal cortex (PPC) and lateral premotor cortex (LPMC) axis of the dorsal visual stream.

methodsInvasive cortical recordings over the PPC and LPMC were obtained during deep brain stimulation lead implantation surgery. Thirteen PD subjects performed an action selection task, which was constituted by left or right joystick movement with directional visual cuing in the EC condition and internally generated direction selection in the IC condition. Time-resolved neural activities within and between the PPC and LPMC were compared between EC and IC conditions.

resultsReaction times (RT) were significantly faster in the EC condition relative to the IC condition (paired t-test, p = 0.0015). PPC-LPMC inter-site phase synchrony within the β-band (13-35 Hz) was significantly greater in the EC relative to the IC condition. Greater PPC-LPMC β debiased phase lag index (dwPLI) prior to movement onset was correlated with faster reaction times only in the EC condition. Multivariate granger causality (GC) was greater in the EC condition relative to the IC condition, prior to and during movement.

conclusionRelative to IC actions, we report relative increase in inter-site phase synchrony and directional PPC to LPMC connectivity in the β-band during preparation and execution of EC actions. Furthermore, increased strength of connectivity is predictive of faster RT, which are pathologically slow in PD patients. Stronger engagement of the PPC-LPMC cortical network by an EC specifically through the channel of β-modulation is implicated in correcting the pathological slowing of action initiation seen in Parkinson's patients. SIGNIFICANCE: These findings shed light on the electrophysiological mechanisms that underlie motor facilitation in PD patients through visuospatial cuing.

Indexed as

Motor CortexParkinson DiseaseHumansMovementParietal LobePsychomotor PerformanceReaction TimeAction selectionChoice taskDorsal visual streamElectrocorticographyPosterior parietal cortexPremotor cortex

Identifiers

PMID35012844
PMCPMC8941338
OpenAlexW4200378715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.