Evidence map›Paper›PMID 35012806›Full record

ArticleAmerican journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics2022

Vitamin E enriched diet increases the rate of orthodontic tooth movement.

Christina Seong, Po-Jung Chen, Zana Kalajzic, Shivam Mehta, Ambika Sharma, Ravindra Nanda, Sumit Yadav, Eliane H Dutra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christina SeongDivision of Orthodontics, University of Connecticut Health Center, Farmington, Conn.
Po-Jung ChenDivision of Orthodontics, University of Connecticut Health Center, Farmington, Conn.
Zana KalajzicDepartment of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, Conn.
Shivam MehtaDivision of Orthodontics, University of Connecticut Health Center, Farmington, Conn.
Ambika SharmaSchool of Dental Medicine, University of Connecticut Health Center, Farmington, Conn.
Ravindra NandaDivision of Orthodontics, University of Connecticut Health Center, Farmington, Conn.
Sumit YadavDivision of Orthodontics, University of Connecticut Health Center, Farmington, Conn.
Eliane H DutraDivision of Orthodontics, University of Connecticut Health Center, Farmington, Conn. Electronic address: edutra@uchc.edu.
UConn Health · US

Funding

The role of FGFR3 in the effects of PTH in the Mandibular CondyleK01DE029528 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DUTRA, ELIANE · 2020 to 2024
$934k
NIDCR NIH HHS K01 DE029528
6 · The paper itself

Abstract

introductionVitamin E is a popular antioxidant suggested to affect bone turnover. However, the effects of a vitamin E enriched diet on the rate of tooth movement are unknown. Therefore, this study aimed to evaluate tooth movement in rats receiving a vitamin E enriched diet. In addition, we examined bone remodeling in experimental and control rats.

methodsThirty-two 6-week-old male rats were divided into 4 groups: (1) group 1 (n = 8): orthodontic tooth movement (OTM) for 4 days + regular diet; (2) group 2 (n = 8): OTM for 14 days + regular diet; (3) group 3 (n = 8): OTM for 4 days + vitamin E diet; and (4) group 4 (n = 8) - OTM for 14 days + vitamin E diet. Maxillary alveolar bones and femurs of rats were analyzed by microcomputed tomography and histology.

resultsRats fed a vitamin E diet presented an increased OTM rate at days 4 and 14. We found an increased number of osteoclasts and decreased bone volume in the vitamin E diet group at day 14 of OTM. In addition, there was increased expression of the microphthalmia-associated transcription factor in the alveolar bone of the vitamin E diet group. In contrast, there was no difference in bone remodeling in femurs or alveolar bone at the control side.

conclusionsWe found that an enriched vitamin E diet increases the rate of OTM in rats, suggesting that vitamin E may be useful as an avenue to accelerate OTM.

Indexed as

Tooth Movement TechniquesVitamin EAnimalsBone RemodelingDietHumansMaleMaxillaOsteoclastsRatsX-Ray MicrotomographyVitamin E

Identifiers

PMID35012806
PMCPMC9050852
OpenAlexW4205109923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.