ArticleFluids and barriers of the CNS2022
The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients.
Article in Fluids and barriers of the CNS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Endovascular Treatment of Hydrocephalus: A Systematic Literature Review.Clinical neuroradiology · 2026Pooled it
- Gait characteristics in idiopathic normal pressure hydrocephalus: a review on the effects of CSF tap test and shunt surgery.European journal of medical research · 2024Pooled it
- [Frequent neurosurgically treatable diseases in geriatric patients].Zeitschrift fur Gerontologie und Geriatrie · 2026Article
- Cognitive Processing Speed Assessment Combined With Gait Performance Improves Prediction of Shunt Surgery Responsiveness in Idiopathic Normal Pressure Hydrocephalus.CNS neuroscience & therapeutics · 2026Article
- MRI-based cerebrospinal fluid volumetric indices for predicting tap test response in idiopathic normal pressure hydrocephalus.Radiological physics and technology · 2026Observational
- Clinical characteristics and outcomes after shunt surgery in idiopathic normal pressure hydrocephalus with or without prior cerebrospinal fluid tap testing: a single-center follow-up study of 481 patients.Fluids and barriers of the CNS · 2026Article
- Sensitivity of physiotherapy-based clinical tests in detecting change in gait and balance performance following a 50 mL CSF tap test in idiopathic normal pressure hydrocephalus.Fluids and barriers of the CNS · 2026Article
- 6-minute walk test and the 3-metre backward walk test are sensitive to postoperative gait improvement in idiopathic normal pressure hydrocephalus.BMJ neurology open · 2026Article
- Role of the Functional Gait Assessment in Validating Item Difficulty Hierarchy and Fall Risk for Idiopathic Normal Pressure Hydrocephalus.Movement disorders clinical practice · 2025Article
- Physical activity and gait in patients with idiopathic normal pressure hydrocephalus: a literature review.Frontiers in neurology · 2025Review
- Quantitative analysis of gait and balance using deep learning on monocular videos and the timed up and go test in idiopathic normal-pressure hydrocephalus.Frontiers in aging neuroscience · 2025Article
- Peripheral immunity patterns, imaging features, and clinical outcomes in patients with gait impairment and ventriculomegaly on brain MRI.Frontiers in aging neuroscience · 2025Article
- Symptoms and signs did not predict outcome after surgery: a prospective study of 143 patients with idiopathic normal pressure hydrocephalus.Journal of neurology · 2024Observational
- Charlson comorbidity index applied to shunted idiopathic normal pressure hydrocephalus.Scientific reports · 2023Article
- Useful outcome measures in INPH patients evaluation.Frontiers in neurology · 2023Article
- Physical Capacity and Activity in Patients With Idiopathic Normal Pressure Hydrocephalus.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to describe the outcome measure timed up and go (TUG) in a large, nationwide cohort of patients with idiopathic normal pressure hydrocephalus (iNPH) pre- and post-operatively. Furthermore, to compare the TUG test to the 10-m walk test (10MWT), the iNPH scale, the modified Rankin scale (mRS) and the Mini Mental State Examination (MMSE), which are commonly applied in clinical assessment of iNPH.
methodsPatients with iNPH (n = 1300), registered in the Swedish Hydrocephalus Quality Registry (SHQR), were included. All data were retrieved from the SHQR except the 10MWT, which was collected from patient medical records. Clinical scales were examined pre- and 3 months post-operatively. Data were dichotomised by sex, age, and preoperative TUG time.
resultsPreoperative TUG values were 19.0 [14.0-26.0] s (median [IQR]) and 23 [18-30] steps. Post-operatively, significant improvements to 14.0 [11.0-20.0] s and 19 [15-25] steps were seen. TUG time and steps were higher in women compared to men (p < 0.001) but there was no sex difference in improvement rate. Worse preoperative TUG and younger age favoured improvement. TUG was highly correlated to the 10MWT, but correlations of post-operative changes were only low to moderate between all scales (r = 0.22-0.61).
conclusionsThis study establishes the distribution of TUG in iNPH patients and shows that the test captures important clinical features that improve after surgery independent of sex and in all age groups, confirming the clinical value of the TUG test. TUG performance is associated with performance on the 10MWT pre- and post-operatively. However, the weak correlations in post-operative change to the 10MWT and other established outcome measures indicate an additional value of TUG when assessing the effects of shunt surgery.
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