Evidence map›Paper›PMID 35012576›Full record

Observational studyItalian journal of pediatrics2022

Altered microstructure of the splenium of corpus callosum is associated with neurodevelopmental impairment in preterm infants with necrotizing enterocolitis.

Jong Ho Cha, Jung-Sun Lim, Yong Hun Jang, Jae Kyoon Hwang, Jae Yoon Na, Jong-Min Lee, Hyun Ju Lee, Ja-Hye Ahn

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Italian journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jong Ho Cha *Department of Pediatrics, Hanyang University College of Medicine, 222-1 Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea.
Jung-Sun Lim *Department of Family Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
Yong Hun JangDepartment of Biomedical Engineering, Hanyang University, Seoul, South Korea.
Jae Kyoon HwangDepartment of Pediatrics, Hanyang University College of Medicine, 222-1 Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea.
Jae Yoon NaDepartment of Pediatrics, Hanyang University College of Medicine, 222-1 Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea.
Jong-Min LeeDepartment of Biomedical Engineering, Hanyang University, Seoul, South Korea.
Hyun Ju LeeDepartment of Pediatrics, Hanyang University College of Medicine, 222-1 Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea.
Ja-Hye AhnDepartment of Pediatrics, Hanyang University College of Medicine, 222-1 Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea. mdscully@gmail.com.

Funding

Hanyang University HY-2017National Research Foundation of Korea Grant funded by the Korean Government MSIT 2020M3E5D9080787National Research Foundation of Korea Grant funded by the Korean Government MSIT 2020R1F1A1048529
6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) is a devastating disease in preterm infants with significant morbidities, including neurodevelopmental impairment (NDI). This study aimed to investigate whether NEC is associated with (1) brain volume expansion and white matter maturation using diffusion tensor imaging analysis and (2) NDI compared with preterm infants without NEC.

methodsWe included 86 preterm infants (20 with NEC and 66 without NEC) with no evidence of brain abnormalities on trans-fontanelle ultrasonography and magnetic resonance imaging at term-equivalent age (TEA). Regional brain volume analysis and white matter tractography were performed to study brain microstructure alterations. NDI was assessed using the Bayley Scales of Infant and Toddler Development-III (BSID-III) at 18 months of corrected age (CA).

resultsPreterm infants with NEC showed significantly high risk of motor impairment (odds ratio 58.26, 95% confidence interval 7.80-435.12, p < 0.001). We found significantly increased mean diffusivity (MD) in the splenium of corpus callosum (sCC) (p = 0.001) and the left corticospinal tract (p = 0.001) in preterm infants with NEC. The sCC with increased MD showed a negative association with the BSID-III language (p = 0.025) and motor scores (p = 0.002) at 18 months of CA, implying the relevance of sCC integrity with later NDI.

conclusionThe white matter microstructure differed between preterm infants with and without NEC. The prognostic value of network parameters of sCC at TEA may provide better information for the early detection of NDI in preterm infants.

Indexed as

Infant, PrematureInfant, Premature, DiseasesCorpus CallosumDevelopmental DisabilitiesDiffusion Tensor ImagingEnterocolitis, NecrotizingFemaleHumansInfant, NewbornMagnetic Resonance ImagingMaleProspective StudiesPyramidal TractsBrain microstructureCorpus callosumDiffusion tensor imagingNecrotizing enterocolitisNeurodevelopmental impairmentThe Bayley scales of infant and toddler developmentVery-low-birth-weight infantWhite matter tracts

Identifiers

PMID35012576
PMCPMC8750779

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.