Evidence map›Paper›PMID 35012551›Full record

ArticleEnvironmental health : a global access science source2022

Prenatal exposure to organophosphate pesticides and risk-taking behaviors in early adulthood.

Sharon K Sagiv, Stephen Rauch, Katherine R Kogut, Carly Hyland, Robert B Gunier, Ana M Mora, Asa Bradman, Julianna Deardorff, Brenda Eskenazi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sharon K SagivCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA, 94720, USA. sagiv@berkeley.edu.ORCID 0000-0003-2245-1905
Stephen RauchCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA, 94720, USA.
Katherine R KogutCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA, 94720, USA.
Carly HylandCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA, 94720, USA.
Robert B GunierCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA, 94720, USA.
Ana M MoraCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA, 94720, USA.
Asa BradmanCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA, 94720, USA.
Julianna DeardorffCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA, 94720, USA.
Brenda EskenaziCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, 1995 University Avenue, Suite 265, Berkeley, CA, 94720, USA.
Center for Environmental Health · USUniversity of California, Merced · US

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
Effect of early life exposure to social adversity and pesticides on risk-taking behavior of 16-18 year olds: the CHAMACOS studyR01ES026994 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2016 to 2020
$3.9M
Early Adversity Shapes Adolescent Risk Behavior Trajectories in Mexican Americans (Diversity Supplement)R01DA035300 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DEARDORFF, JULIANNA · 2014 to 2018
$3.1M
PBDEs, DDT and Neurodevelopment in School-Aged Mexican-American ChildrenR01ES015572 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2007 to 2010
$2.0M
Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future GenerationsR24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Robert Gunier · 2017 to 2026
$2.0M
NIDA NIH HHS R01 DA035300NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R01 ES015572NIEHS NIH HHS R01 ES026994NIEHS NIH HHS R24 ES028529U.S. Environmental Protection Agency RD 82670901U.S. Environmental Protection Agency RD 83171001U.S. Environmental Protection Agency RD 83451301
6 · The paper itself

Abstract

introductionPrevious studies show evidence for associations of prenatal exposure to organophosphate (OP) pesticides with poorer childhood neurodevelopment. As children grow older, poorer cognition, executive function, and school performance can give rise to risk-taking behaviors, including substance abuse, delinquency, and violent acts. We investigated whether prenatal OP exposure was associated with these risk-taking behaviors in adolescence and young adulthood in a Mexican American cohort.

methodsWe measured urinary dialkyl phosphates (DAPs), non-specific metabolites of OPs, twice (13 and 26 weeks gestation) in pregnant women recruited in 1999-2000 in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a birth cohort set in a primarily Latino agricultural community in the Salinas Valley, California. We followed up children throughout their childhood and adolescence; at the 18-year visit, adolescent youth (n = 315) completed a computer-based questionnaire which included questions about substance use, risky sexual activity, risky driving, and delinquency and police encounters. We used multivariable models to estimate associations of prenatal total DAPs with these risk-taking behaviors.

resultsThe prevalence of risk-taking behaviors in CHAMACOS youth ranged from 8.9% for smoking or vaping nicotine to 70.2% for committing a delinquent act. Associations of total prenatal DAPs (geometric mean = 132.4 nmol/L) with risk-taking behavior were generally null and imprecise. Isolated findings included a higher risk for smoking or vaping nicotine within the past 30 days (relative risk [RR] per 10-fold increase in prenatal DAPs = 1.89, 95% CI: 1.00, 3.56) and driving without a license (RR = 1.74, 95% CI: 1.25, 2.42). There were no consistent differences by sex or childhood adversity. DISCUSSION: We did not find clear or consistent evidence for associations of prenatal OP exposure with risk-taking behaviors in adolescence/early adulthood in the CHAMACOS population. Our small sample size may have prevented us from detecting potentially subtle associations of early life OP exposure with these risk-taking behaviors.

Indexed as

PesticidesPrenatal Exposure Delayed EffectsAdolescentAdultChildEnvironmental ExposureFemaleHumansOrganophosphatesPregnancyRisk-TakingYoung AdultOrganophosphatesPesticidesDelinquencyOrganophosphatesPesticidesPrenatal exposureRisky behaviorRisky drivingSexual behaviorSubstance use

Identifiers

PMID35012551
PMCPMC8751255
OpenAlexW4226472655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.