Evidence map›Paper›PMID 35012474›Full record

ArticleBMC geriatrics2022

Explanatory role of sociodemographic, clinical, behavioral, and social factors on cognitive decline in older adults with diabetes.

Sean M O'Toole, Rebekah J Walker, Emma Garacci, Aprill Z Dawson, Jennifer A Campbell, Leonard E Egede

Open access · goldAbstract read
In one paragraph

Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sean M O'TooleCollege of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Rebekah J WalkerDivision of General Internal Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Emma GaracciCenter for Advancing Population Science (CAPS), Medical College of Wisconsin, Milwaukee, WI, USA.
Aprill Z DawsonDivision of General Internal Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Jennifer A CampbellDivision of General Internal Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Leonard E EgedeDivision of General Internal Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. legede@mcw.edu.
Medical College of Wisconsin · US

Funding

HOME DM-BAT: Home-based Diabetes-Modified Behavioral Activation Treatment for Low Income Seniors with T2DM Diversity SupplementR01DK118038 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EGEDE, LEONARD E. · 2019 to 2023
$3.5M
Financial Incentives And Nurse Coaching to Enhance Diabetes Outcomes (FINANCE-DM) - Diversity SupplementR01DK120861 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EGEDE, LEONARD E. · 2019 to 2023
$3.4M
Lowering the Impact of Food insecurity in African American Adults with Type 2 Diabetes Mellitus (LIFT-DM) - Diversity SupplementR01MD013826 · NIMHD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EGEDE, LEONARD E., WALKER, REBEKAH J · 2019 to 2023
$3.4M
Technology Intensified Diabetes Education Study in AA with T2DM (TIDES)K24DK093699 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI EGEDE, LEONARD E. · 2011 to 2020
$1.5M
Medical Student Training in Aging and Injury ResearchT35AG029793 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI MEURER, LINDA N. · 2007 to 2021
$1.0M
NIA NIH HHS T35 AG029793NIDDK NIH HHS K24 DK093699NIDDK NIH HHS R01 DK118038NIDDK NIH HHS R01 DK120861NIMHD NIH HHS R01 MD013826
6 · The paper itself

Abstract

backgroundThe aim of the study was to examine the explanatory role of sociodemographic, clinical, behavioral, and social factors on racial/ethnic differences in cognitive decline among adults with diabetes.

methodsAdults aged 50+ years with diabetes from the Health and Retirement Survey were assessed for cognitive function (normal, mild cognitive impairment [MCI], and dementia). Generalized estimating equation (GEE) logistic regression models were used to account for repeating measures over time. Models were adjusted for sociodemographic (gender, age, education, household income and assets), behavioral (smoking), clinical (ie. comorbidities, body mass index), and social (social support, loneliness, social participation, perceived constraints and perceived mastery on personal control) factors.

resultsUnadjusted models showed non-Hispanic Blacks (NHB) and Hispanics were significantly more likely to progress from normal cognition to dementia (NHB OR: 2.99, 95%CI 2.35-3.81; Hispanic OR: 3.55, 95%CI 2.77-4.56), and normal cognition to MCI (NHB OR = 2.45, 95%CI 2.14-2.82; Hispanic OR = 2.49, 95%CI 2.13-2.90) compared to non-Hispanic Whites (NHW). Unadjusted models for the transition from mild cognitive decline to dementia showed Hispanics were more likely than NHW to progress (OR = 1.43, 95%CI 1.11-1.84). After adjusting for sociodemographic, clinical/behavioral, and social measures, NHB were 3.75 times more likely (95%CI 2.52-5.56) than NHW to reach dementia from normal cognition. NHB were 2.87 times more likely (95%CI 2.37-3.48) than NHW to reach MCI from normal. Hispanics were 1.72 times more likely (95%CI 1.17-2.52) than NHW to reach dementia from MCI.

conclusionClinical/behavioral and social factors did not explain racial/ethnic disparities. Racial/ethnic disparities are less evident from MCI to dementia, emphasizing preventative measures/interventions before cognitive impairment onset are important.

Indexed as

Cognitive DysfunctionDiabetes MellitusAgedBlack or African AmericanHumansSocial FactorsWhite PeopleCognitive declinediabeteselderlyHealth and Retirement Surveyhealth disparities

Identifiers

PMID35012474
PMCPMC8751249
OpenAlexW4205664432

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.