Evidence map›Paper›PMID 35012355›Full record

ArticlemBio2022

Fungal Extracellular Vesicles Are Involved in Intraspecies Intracellular Communication.

Tamires A Bitencourt, Otavio Hatanaka, Andre M Pessoni, Mateus S Freitas, Gabriel Trentin, Patrick Santos, Antonio Rossi, Nilce M Martinez-Rossi, Lysangela L Alves, Arturo Casadevall and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
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  5. Biomolecular Corona Remodelling ofJournal of extracellular biology · 2026
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  10. International journal of molecular sciences · 2026
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  11. Selective DNA encapsulation in extracellular vesicles ofExtracellular vesicles and circulating nucleic acids · 2026
    Article
  12. Article
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  14. Growth conditions shape the proteome and diversity ofCell surface (Amsterdam, Netherlands) · 2025
    Article
  15. Article
  16. Article
  17. Extracellular vesicles from DistinctACS infectious diseases · 2025
    Article
  18. Fungal biofilms in human health and disease.Nature reviews. Microbiology · 2025
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Tamires A BitencourtDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.ORCID 0000-0001-7373-3780
Otavio HatanakaDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
Andre M PessoniDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
Mateus S FreitasDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
Gabriel TrentinDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
Patrick SantosDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
Antonio RossiDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Nilce M Martinez-RossiDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID 0000-0002-5723-4276
Lysangela L AlvesGene Expression Regulation Laboratory, Carlos Chagas Institute, Fiocruz, Curitiba, PR, Brazil.ORCID 0000-0002-1972-2658
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-9402-9167
Marcio L RodriguesGene Expression Regulation Laboratory, Carlos Chagas Institute, Fiocruz, Curitiba, PR, Brazil.
Fausto AlmeidaDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.ORCID 0000-0002-3782-3698
Universidade de São Paulo · BRFundação Carlos Chagas · BRJohns Hopkins University · USUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal infections are associated with high mortality rates in humans. The risk of fungal diseases creates the urgent need to broaden the knowledge base regarding their pathophysiology. In this sense, the role of extracellular vesicles (EVs) has been described to convey biological information and participate in the fungus-host interaction process. We hypothesized that fungal EVs work as an additional element in the communication routes regulating fungal responses in intraspecies interaction systems. In this respect, the aim of this study was to address the gene regulation profiles prompted by fungal EVs in intraspecies recipient cells. Our data demonstrated the intraspecies uptake of EVs in pathogenic fungi, such as Candida albicans, Aspergillus fumigatus, and Paracoccidioides brasiliensis, and the effects triggered by EVs in fungal cells. In C. albicans, we evaluated the involvement of EVs in the yeast-to-hypha transition, while in

Indexed as

Extracellular VesiclesMycosesAntifungal AgentsAspergillus fumigatusCandida albicansCell CommunicationHumansAntifungal AgentsAspergillus fumigatusCandida albicanscellular communicationextracellular vesiclesfungal biologyfungal infectionsParacoccidioides brasiliensis

Identifiers

PMID35012355
PMCPMC8749427
OpenAlexW4220708303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.