ArticlemBio2022
Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection.
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Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
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19 citing papers in PubMed, 24 citations in OpenAlex.
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Authors and funding
23 authors at 3 institutions in 2 countries.
David M P De OliveiraThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Brian M FordeThe University of Queenslandgrid.1003.2, UQ Centre for Clinical Research, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.ORCID 0000-0002-2264-4785
Minh-Duy PhanThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.ORCID 0000-0002-3426-1044
Bernhard SteinerThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Bing ZhangThe University of Queenslandgrid.1003.2, Centre for Superbug Solutions, Institute for Molecular Bioscience, Brisbane, QLD, Australia.
Johannes ZueggThe University of Queenslandgrid.1003.2, Centre for Superbug Solutions, Institute for Molecular Bioscience, Brisbane, QLD, Australia.
Ibrahim M El-DeebGriffith University, Institute for Glycomics, Gold Coast, QLD, Australia.
Gen LiThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Nadia KellerThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Stephan BrouwerThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Nichaela Harbison-PriceThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Amanda J CorkThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Michelle J BauerThe University of Queenslandgrid.1003.2, UQ Centre for Clinical Research, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Saleh F AlquethamyThe University of Melbournegrid.1008.9, Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Scott A BeatsonThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.ORCID 0000-0002-1806-3283
Jason A RobertsThe University of Queenslandgrid.1003.2, UQ Centre for Clinical Research, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.ORCID 0000-0001-6218-435X
David L PatersonThe University of Queenslandgrid.1003.2, UQ Centre for Clinical Research, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Alastair G McEwanThe University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
Mark A T BlaskovichThe University of Queenslandgrid.1003.2, Centre for Superbug Solutions, Institute for Molecular Bioscience, Brisbane, QLD, Australia.
Mark A Schembri *The University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.ORCID 0000-0003-4863-9260
Christopher A McDevitt *The University of Melbournegrid.1008.9, Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID 0000-0003-1596-4841
Mark von Itzstein *Griffith University, Institute for Glycomics, Gold Coast, QLD, Australia.ORCID 0000-0001-6302-7524
Mark J Walker *The University of Queenslandgrid.1003.2, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia.
The University of Queensland · AUGriffith University · AUThe University of Melbourne · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acinetobacter baumannii causes high mortality in ventilator-associated pneumonia patients, and antibiotic treatment is compromised by multidrug-resistant strains resistant to β-lactams, carbapenems, cephalosporins, polymyxins, and tetracyclines. Among COVID-19 patients receiving ventilator support, a multidrug-resistant A. baumannii secondary infection is associated with a 2-fold increase in mortality. Here, we investigated the use of the 8-hydroxyquinoline ionophore PBT2 to break the resistance of A. baumannii to tetracycline class antibiotics.
Indexed as
Acinetobacter baumanniiAcinetobacter InfectionsCOVID-19Pneumonia, Ventilator-AssociatedAnimalsAnti-Bacterial Agentsbeta-LactamsCarbapenemsDrug Resistance, Multiple, BacterialHumansMiceMicrobial Sensitivity TestsPandemicsTetracyclineTigecyclineZincAnti-Bacterial Agentsbeta-LactamsCarbapenemsTetracyclineTigecyclineZincAcinetobacterantibiotic resistanceionophorestetracyclines
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.