Evidence map›Paper›PMID 35012346›Full record

ArticlemBio2022

Complement Receptor 3 Mediates HIV-1 Transcytosis across an Intact Cervical Epithelial Cell Barrier: New Insight into HIV Transmission in Women.

Christopher J Day, Rachael L Hardison, Belinda L Spillings, Jessica Poole, Joseph A Jurcisek, Johnson Mak, Michael P Jennings, Jennifer L Edwards

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Christopher J Day *Institute for Glycomics, Griffith Universitygrid.1022.1, Southport, Queensland, Australia.
Rachael L Hardison *Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Belinda L SpillingsInstitute for Glycomics, Griffith Universitygrid.1022.1, Southport, Queensland, Australia.
Jessica PooleInstitute for Glycomics, Griffith Universitygrid.1022.1, Southport, Queensland, Australia.
Joseph A JurcisekCenter for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Johnson MakInstitute for Glycomics, Griffith Universitygrid.1022.1, Southport, Queensland, Australia.
Michael P JenningsInstitute for Glycomics, Griffith Universitygrid.1022.1, Southport, Queensland, Australia.ORCID 0000-0002-1027-4684
Jennifer L EdwardsCenter for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0003-3568-0344
Griffith University · AUNationwide Children's Hospital · US

Funding

Novel carbohydrate binding functions of the CR3 I-domain modulate gonococcal-cervical cell interactionsR01AI134848 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI EDWARDS, JENNIFER L, JENNINGS, MICHAEL PAUL · 2018 to 2022
$2.2M
NIAID NIH HHS R01 AI134848
6 · The paper itself

Abstract

Transmission of HIV across the mucosal surface of the female reproductive tract to engage subepithelial CD4-positive T cells is not fully understood. Cervical epithelial cells express complement receptor 3 (CR3) (integrin α

Indexed as

HIV-1HIV InfectionsHIV SeropositivityAnimalsCHO CellsCricetinaeCricetulusEpithelial CellsFemaleHumansMacrophage-1 AntigenPolysaccharidesTranscytosisMacrophage-1 AntigenPolysaccharidescarbamazepinecervical epithelial cellscomplement receptor 3HIVhuman immunodeficiency virusmethyldopatranscytosis

Identifiers

PMID35012346
PMCPMC8749410
OpenAlexW4205105522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.