Evidence map›Paper›PMID 35012341›Full record

ArticlemBio2022

Systematic Genetic Interaction Analysis Identifies a Transcription Factor Circuit Required for Oropharyngeal Candidiasis.

Norma V Solis, Rohan S Wakade, Virginia E Glazier, Tomye L Ollinger, Melanie Wellington, Aaron P Mitchell, Scott G Filler, Damian J Krysan

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. The unique Efg1 fungal virulence regulon in the catheterized bladder environment.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  3. Article
  4. Article
  5. Review
  6. Host immune response against fungal biofilms.Current opinion in microbiology · 2024
    Review
  7. Article
  8. Article
  9. ThebioRxiv : the preprint server for biology · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Host's Immunity andMicroorganisms · 2022
    Review
  14. Article
  15. Article
  16. Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Norma V SolisDivision of Infectious Diseases, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Rohan S WakadeDepartment of Pediatrics, Carver College of Medicine, University of Iowagrid.412584.egrid.214572.7, Iowa City, Iowa, USA.
Virginia E GlazierDepartment of Biology, Niagara University, Niagara Falls, New York, USA.
Tomye L OllingerDepartment of Pediatrics, Carver College of Medicine, University of Iowagrid.412584.egrid.214572.7, Iowa City, Iowa, USA.
Melanie WellingtonDepartment of Pediatrics, Carver College of Medicine, University of Iowagrid.412584.egrid.214572.7, Iowa City, Iowa, USA.
Aaron P MitchellDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-0868-4000
Scott G FillerDivision of Infectious Diseases, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Damian J KrysanDepartment of Pediatrics, Carver College of Medicine, University of Iowagrid.412584.egrid.214572.7, Iowa City, Iowa, USA.ORCID 0000-0001-6330-3365
University of Iowa · USNiagara University · USUCLA Medical Center · USUniversity of California, Los Angeles · USUniversity of Georgia · US

Funding

C. albicans invasion and proliferation during oral infectionR01DE026600 · NIDCR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G, MITCHELL, AARON P · 2017 to 2021
$3.0M
Complex haploinsufficiency based genetic analysis of C. albicans pathogenesisR01AI133409 · NIAID · UNIVERSITY OF IOWA · PI KRYSAN, DAMIAN J · 2018 to 2022
$2.5M
NIAID NIH HHS R01 AI133409NIDCR NIH HHS R01 DE026600
6 · The paper itself

Abstract

Oropharyngeal candidiasis (OPC) is a common infection that complicates a wide range of medical conditions and can cause either mild or severe disease depending on the patient. The pathobiology of OPC shares many features with candidal biofilms of abiotic surfaces. The transcriptional regulation of C. albicans biofilm formation on abiotic surfaces has been extensively characterized and involves six key transcription factors (Efg1, Ndt80, Rob1, Bcr1, Brg1, and Tec1). To determine if the

Indexed as

Candidiasis, OralAnimalsBiofilmsCandida albicansFungal ProteinsGene Expression Regulation, FungalHomozygoteMiceSequence DeletionTranscription FactorsFungal ProteinsTranscription FactorsbiofilmsCandida albicanscomplex haploinsufficiencyoropharyngeal candidiasis

Identifiers

PMID35012341
PMCPMC8749425
OpenAlexW4205635481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.