ArticleCirculation research2022
Epigenetic Regulation of
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Article in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- A systematic review of observational studies on long-term air pollution exposure and epigenetic alterations in adults.Journal of global health · 2026Pooled it
- DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites.Clinical epigenetics · 2023Pooled it
- Multiomic Reference Map of Endothelial Mechanosensitive Pathways Under Athero- and Erosion-Prone Flow.Journal of the American Heart Association · 2026Article
- Metabolic Reprogramming-Driven Cardiovascular Immune Damage: From Glyco-Lipotoxicity and Epigenetic Memory to Multidimensional Cross-Organ Communication Networks.International journal of molecular sciences · 2026Review
- Changes of DNA methylation in smokers and ex-smokers referred for coronary angiography. Results from the LURIC study.Clinical epigenetics · 2026Article
- The Future of Epigenetics: Emerging Technologies and Clinical Applications.ACS pharmacology & translational science · 2026Review
- Diagnosis of head and neck cancer by AI-based tumor-educated platelet RNA profiling of liquid biopsies.JCI insight · 2026Article
- DNA Methylation Variation in Blood Cells may Impact Platelet Function.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Roles of different methylation modifications in cardiovascular disease.Frontiers of medicine · 2025Review
- GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway.Cellular & molecular biology letters · 2025Article
- Environmental pollutants and atherosclerosis: Epigenetic mechanisms linking genetic risk and disease.Atherosclerosis · 2025Review
- Endothelial protease-activated receptor 4: impotent or important?Frontiers in cardiovascular medicine · 2025Review
- Epigenetic regulation of cardiovascular diseases induced by behavioral and environmental risk factors: Mechanistic, diagnostic, and therapeutic insights.FASEB bioAdvances · 2024Review
- Integrated Bioinformatics Analysis Reveals the Aberrantly Methylated Differentially Expressed Genes in Dilated Cardiomyopathy.International journal of medical sciences · 2024Article
- From multi-omics approaches to personalized medicine in myocardial infarction.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 6 institutions in 4 countries.
Laura J CorbinMRC Integrative Epidemiology Unit at University of Bristol, United Kingdom (L.J.C., L.F., A.G., L.P., M.R.M., C.R., J.L.M., G.D.S., N.J.T.).ORCID 0000-0002-4032-9500
Stephen J WhiteDepartment of Life Sciences, Manchester Metropolitan University, United Kingdom (S.J.W.).ORCID 0000-0003-0090-6358
Amy E TaylorPopulation Health Sciences, Bristol Medical School (L.J.C., A.E.T., K.T., L.F., A.G., L.P., C.R., J.L.M., G.D.S., N.J.T.), University of Bristol, United Kingdom.
Christopher M WilliamsPopulation Health Sciences, Bristol Medical School (L.J.C., A.E.T., K.T., L.F., A.G., L.P., C.R., J.L.M., G.D.S., N.J.T.), University of Bristol, United Kingdom.
Kurt TaylorPopulation Health Sciences, Bristol Medical School (L.J.C., A.E.T., K.T., L.F., A.G., L.P., C.R., J.L.M., G.D.S., N.J.T.), University of Bristol, United Kingdom.ORCID 0000-0003-4690-063X
Marion T van den BoschSchool of Physiology, Pharmacology and Neuroscience (C.M.W., M.T.v.d.B., A.W.P.), University of Bristol, United Kingdom.ORCID 0000-0002-4635-4416
Jack E TeasdaleTranslational Health Sciences, Bristol Medical School (J.E.T., M.J., M.B.), University of Bristol, United Kingdom.
Matthew JonesTranslational Health Sciences, Bristol Medical School (J.E.T., M.J., M.B.), University of Bristol, United Kingdom.
Mark BondTranslational Health Sciences, Bristol Medical School (J.E.T., M.J., M.B.), University of Bristol, United Kingdom.
Matthew T HarperDepartment of Pharmacology, University of Cambridge, Tennis Court Road (M.T.H., G.G.J.H.).
Louise FalkMRC Integrative Epidemiology Unit at University of Bristol, United Kingdom (L.J.C., L.F., A.G., L.P., M.R.M., C.R., J.L.M., G.D.S., N.J.T.).
Alix GroomMRC Integrative Epidemiology Unit at University of Bristol, United Kingdom (L.J.C., L.F., A.G., L.P., M.R.M., C.R., J.L.M., G.D.S., N.J.T.).
Georgina G J HazellDepartment of Pharmacology, University of Cambridge, Tennis Court Road (M.T.H., G.G.J.H.).
Lavinia PaternosterMRC Integrative Epidemiology Unit at University of Bristol, United Kingdom (L.J.C., L.F., A.G., L.P., M.R.M., C.R., J.L.M., G.D.S., N.J.T.).
Marcus R MunafòMRC Integrative Epidemiology Unit at University of Bristol, United Kingdom (L.J.C., L.F., A.G., L.P., M.R.M., C.R., J.L.M., G.D.S., N.J.T.).
Børge G NordestgaardDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital (B.G.N., S.E.B.), Copenhagen University Hospital, Denmark.ORCID 0000-0002-1954-7220
Anne Tybjærg-HansenThe Copenhagen City Heart Study, Frederiksberg Hospital (B.G.N., A.T.-H., S.E.B.), Copenhagen University Hospital, Denmark.
Stig E BojesenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital (B.G.N., S.E.B.), Copenhagen University Hospital, Denmark.
Caroline ReltonMRC Integrative Epidemiology Unit at University of Bristol, United Kingdom (L.J.C., L.F., A.G., L.P., M.R.M., C.R., J.L.M., G.D.S., N.J.T.).
Josine L MinMRC Integrative Epidemiology Unit at University of Bristol, United Kingdom (L.J.C., L.F., A.G., L.P., M.R.M., C.R., J.L.M., G.D.S., N.J.T.).ORCID 0000-0003-4456-9824
George Davey SmithMRC Integrative Epidemiology Unit at University of Bristol, United Kingdom (L.J.C., L.F., A.G., L.P., M.R.M., C.R., J.L.M., G.D.S., N.J.T.).ORCID 0000-0002-1407-8314
Andrew D MumfordSchool of Cellular and Molecular Medicine (A.D.M.), University of Bristol, United Kingdom.ORCID 0000-0002-5523-511X
Alastair W PooleSchool of Physiology, Pharmacology and Neuroscience (C.M.W., M.T.v.d.B., A.W.P.), University of Bristol, United Kingdom.ORCID 0000-0002-0868-297X
Nicholas J TimpsonMRC Integrative Epidemiology Unit at University of Bristol, United Kingdom (L.J.C., L.F., A.G., L.P., M.R.M., C.R., J.L.M., G.D.S., N.J.T.).
University of Bristol · GBUniversity of Copenhagen · DKUniversity of Tennessee Health Science Center · USManchester Metropolitan University · GBUK Centre for Tobacco & Alcohol Studies · GBUniversity Hospitals Bristol NHS Foundation Trust · GB
Funding
British Heart Foundation AA/18/1/34219British Heart Foundation CH95/001British Heart Foundation FS/12/77/29887British Heart Foundation FS/17/60/33474British Heart Foundation PG/11/44/28972British Heart Foundation PG/13/14/30023British Heart Foundation PG/15/96/31854British Heart Foundation PG/17/67/33218British Heart Foundation RG/15/16/31758Cancer Research UK 29019Cancer Research UK C18281/A29019Medical Research Council MC_PC_15018Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/7Medical Research Council MC_UU_12013/3Wellcome Trust 202802/Z/16/ZWellcome Trust 217065/Z/19/ZWellcome Trust 219472/Z/19/Z
Abstract
backgroundDNA hypomethylation at the
methodsWe conducted multiple independent experiments to assess whether DNA hypomethylation at
resultsObservationally, DNA methylation at
conclusionsSmoking-induced epigenetic DNA hypomethylation at
Indexed as
Epigenesis, GeneticAgedBlood PlateletsDNA MethylationFemaleHumansMaleMiddle AgedMyocardial InfarctionReceptors, ThrombinSmokingprotease-activated receptor 4Receptors, Thrombinblood plateletsDNA methylationepigenomicsmyocardial infarctionsmokingthrombintobacco
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.