ArticlePolymers2022
In Vivo Study of Nasal Bone Reconstruction with Collagen, Elastin and Chitosan Membranes in Abstainer and Alcoholic Rats.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Comparison of physical, mechanical and biological properties of a porcine urinary bladder acellular matrix collagen membrane with six other collagen membranes of animal origin.BMC oral health · 2026Article
- Bioprinting in Tissue Repair and Its ENT Applications.Polymers · 2026Review
- Treatment of femoral defects in rats with collagen and elastin polymers combined with hydroxyapatite and bone morphogenetic protein.Frontiers in bioengineering and biotechnology · 2026Article
- Chronic heavy alcohol consumption impairs the ability of demineralized allogenic bone matrix to support osteoinduction in alcohol-naïve rats.Bone reports · 2025Article
- Use of Plant Extracts in Polymeric Scaffolds in the Regeneration of Mandibular Injuries.Pharmaceutics · 2024Article
- Viability of Collagen Matrix Grafts Associated with Nanohydroxyapatite and Elastin in Bone Repair in the Experimental Condition of Ovariectomy.International journal of molecular sciences · 2023Article
- In Vivo Evaluation of Collagen and Chitosan Scaffold, Associated or Not with Stem Cells, in Bone Repair.Journal of functional biomaterials · 2023Article
- Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry.International journal of medical sciences · 2023Review
- Expression, characterization, and application potentiality evaluation of recombinant human-like collagen in Pichia pastoris.Bioresources and bioprocessing · 2022Article
- Progress in Research of Chitosan Chemical Modification Technologies and Their Applications.Marine drugs · 2022Review
- Article
- Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health.Biomolecules · 2022Review
- Graphene Oxide-Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications.Polymers · 2022Review
- Biological Behavior of Xenogenic Scaffolds in Alcohol-Induced Rats: Histomorphometric and Picrosirius Red Staining Analysis.Polymers · 2022Article
Corrections and comments
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Authors and funding
25 authors at 8 institutions in 1 country.
Funding
Abstract
The aim of the present study was to evaluate the use of collagen, elastin, or chitosan biomaterial for bone reconstruction in rats submitted or not to experimental alcoholism. Wistar male rats were divided into eight groups, submitted to chronic alcohol ingestion (G5 to G8) or not (G1 to G4). Nasal bone defects were filled with clot in animals of G1 and G5 and with collagen, elastin, and chitosan grafts in G2/G6, G3/G7, and G4/G8, respectively. Six weeks after, all specimens underwent radiographic, tomographic, and microscopic evaluations. Bone mineral density was lower in the defect area in alcoholic animals compared to the abstainer animals. Bone neoformation was greater in the abstainer groups receiving the elastin membrane and in abstainer and alcoholic rats receiving the chitosan membrane (15.78 ± 1.19, 27.81 ± 0.91, 47.29 ± 0.97, 42.69 ± 1.52, 13.81 ± 1.60, 18.59 ± 1.37, 16.54 ± 0.89, and 37.06 ± 1.17 in G1 to G8, respectively). In conclusion, osteogenesis and bone density were more expressive after the application of the elastin matrix in abstainer animals and of the chitosan matrix in both abstainer and alcoholic animals. Chronic alcohol ingestion resulted in lower bone formation and greater formation of fibrous connective tissue.
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Registered trials
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