Evidence map›Paper›PMID 35011975›Full record

ArticleJournal of clinical medicine2022

The Role of Lung Ultrasound in Diagnosing COVID-19-Related Multisystemic Inflammatory Disease: A Preliminary Experience.

Anna Maria Musolino, Elena Boccuzzi, Danilo Buonsenso, Maria Chiara Supino, Maria Alessia Mesturino, Eugenio Pitaro, Valentina Ferro, Raffaella Nacca, Serena Sinibaldi, Paolo Palma and 2 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna Maria MusolinoPediatric Emergency, Department of Emergency and General Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.
Elena BoccuzziPediatric Emergency, Department of Emergency and General Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.
Danilo BuonsensoDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00100 Rome, Italy.ORCID 0000-0001-8567-2639
Maria Chiara SupinoPediatric Emergency, Department of Emergency and General Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.ORCID 0000-0003-2507-8886
Maria Alessia MesturinoPediatric Emergency, Department of Emergency and General Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.
Eugenio PitaroAcademic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.
Valentina FerroPediatric Emergency, Department of Emergency and General Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.
Raffaella NaccaPediatric Emergency, Department of Emergency and General Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.
Serena SinibaldiPediatric Unit, Department of Emergency and General Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00050 Palidoro, Italy.
Paolo PalmaClinical Immunology and Vaccinology Unit, Research Unit in Clinical Immunology and Vaccinology, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.
Alberto VillaniDepartment of Emergency and General Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.ORCID 0000-0002-9120-0424
Paolo TomàDepartment of Imaging, Bambino Gesù Children's Hospital, IRCCS, 00100 Rome, Italy.ORCID 0000-0002-0158-4760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, there are no data regarding the systematic application of Point-of-Care Lung Ultrasound (PoC-LUS) in children with Multisystem Inflammatory Syndrome in Children (MIS-C). The main aim of this study is to show the role of Point-of-Care Lung Ultrasound as an additional aid in the diagnosis of COVID-19-related Multisystem Inflammatory Syndrome in Children (MIS-C).

methodsBetween April 2020 and April 2021, patients aged 0-18 years referred to our emergency department for fever, and later hospitalized without a specific diagnosis, underwent PoC-LUS. Ultrasound images of patients with a final diagnosis of MIS-C were retrospectively evaluated.

resultsTen patients were enrolled. All were described to have pleural irregularities and B-lines. In particular: 8/10 children presented with isolated B-lines in at least half of the lung areas of interest; 8/10 presented with multiple B-lines and 3/8 had them in at least 50% of lung areas; 5/10 had a white lung appearance in at least one lung area and 1/5 had them in half of the areas of interest. Pleural effusion was described in 9/10.

conclusionsDuring the ongoing COVID-19 pandemic, we suggest performing PoC-LUS in febrile patients with high levels of inflammatory indices and clinical suspicion of MIS-C, or without a certain diagnosis; the finding of many B-lines and pleural effusion would support the diagnosis of a systemic inflammatory disease.

Indexed as

childrenlung ultrasoundmultisystem inflammatory syndrome

Identifiers

PMID35011975
PMCPMC8746270

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.