Evidence map›Paper›PMID 35011947›Full record

ArticleJournal of clinical medicine2021

Detection and Prediction of Macrophage Activation Syndrome in Still's Disease.

Clément Javaux, Thomas El-Jammal, Pierre-Antoine Neau, Nicolas Fournier, Mathieu Gerfaud-Valentin, Laurent Perard, Marine Fouillet-Desjonqueres, Julie Le Scanff, Emmanuelle Vignot, Stéphane Durupt and 6 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  6. Observational
  7. Observational
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  14. Review
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  17. Article
  18. Review
  19. Article
  20. Adult-Onset Still's Disease-A Complex Disease, a Challenging Treatment.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Clément JavauxDepartment of Internal Medicine, Croix-Rousse University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69004 Lyon, France.
Thomas El-JammalDepartment of Internal Medicine, Croix-Rousse University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69004 Lyon, France.
Pierre-Antoine NeauDepartment of Internal Medicine, Croix-Rousse University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69004 Lyon, France.
Nicolas FournierDepartment of Internal Medicine, Croix-Rousse University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69004 Lyon, France.ORCID 0000-0002-6496-4496
Mathieu Gerfaud-ValentinDepartment of Internal Medicine, Croix-Rousse University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69004 Lyon, France.ORCID 0000-0003-4245-8039
Laurent PerardDepartment of Internal Medicine, Saint Luc Saint Joseph Hospital, 69007 Lyon, France.
Marine Fouillet-DesjonqueresDepartment of Pediatric Nephrology, Rheumatology, Dermatology, Mère-Enfant Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69500 Bron, France.
Julie Le ScanffDepartment of Internal Medicine, Villefranche-sur-Saône Hospital, 69400 Gleize, France.
Emmanuelle VignotDepartment of Rheumatology, Edouard Herriot University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69003 Lyon, France.
Stéphane DuruptDepartment of Internal Medicine, Lyon-Sud University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69310 Pierre-Benite, France.
Arnaud HotDepartment of Internal Medicine, Edouard Herriot University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69003 Lyon, France.
Alexandre BelotDepartment of Pediatric Nephrology, Rheumatology, Dermatology, Mère-Enfant Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69500 Bron, France.ORCID 0000-0003-4902-5332
Isabelle DurieuDepartment of Internal Medicine, Lyon-Sud University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69310 Pierre-Benite, France.
Thomas HenryCIRI (Centre International de Recherche en Infectiologie), Inserm U1111, CNRS, UMR5308, ENS de Lyon, Université Claude Bernard Lyon 1, 69007 Lyon, France.ORCID 0000-0002-0687-8565
Pascal SèveDepartment of Internal Medicine, Croix-Rousse University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69004 Lyon, France.ORCID 0000-0003-3070-3842
Yvan JamillouxDepartment of Internal Medicine, Croix-Rousse University Hospital, Hospices Civils de Lyon, Université Claude Bernard-Lyon 1, 69004 Lyon, France.ORCID 0000-0001-5249-3650

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Distinguishing between macrophage activation syndrome (MAS) and a simple flare of Still's disease (SD) may be challenging. We sought to clarify the clinical features and outcome of MAS in SD and to explore predictive factors of MAS development. Demographic and clinical data, treatments, and outcomes were recorded in a cohort of 206 SD patients. SD patients with and without MAS were compared. To explore predictive factors for the development of MAS, patients were compared at the time of SD diagnosis. Twenty (9.7%) patients experienced MAS, which was inaugural in 12 cases. Patients with MAS were more likely to have hepatomegaly (OR, 3.71; 95% CI, 1.14-11.2;

Indexed as

adult-onset Still’s diseaseautoinflammatory diseaseferritinmacrophage activation syndromesystemic-onset juvenile idiopathic arthritis

Identifiers

PMID35011947
PMCPMC8745834

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.