ArticleJournal of clinical medicine2021
Factors Associated with the Development of Coagulopathy after Open Traumatic Brain Injury.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stress-induced hyperglycemia and mortality in patients with traumatic brain injury without preexisting diabetes: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- A dynamic nomogram for predicting primary intraoperative brain bulge in patients with traumatic acute subdural hematoma.BMC medical imaging · 2026Article
- Explainable machine learning model for predicting traumatic brain injury-induced coagulopathy in elderly patients: A multicenter cohort study.Neurosurgical review · 2026Article
- An Exploratory Analysis of Potential Core Targets and Signaling Pathways Linking Dexmedetomidine to Diabetes Insipidus: Integration of FAERS Pharmacovigilance Data, Network Toxicology and Clinical Transcriptomics.Drug design, development and therapy · 2026Article
- The Prognostic Value of Inflammatory Indexes in Patients With Severe Traumatic Brain Injury.Brain and behavior · 2025Article
- Hemostatic disturbances in traumatic brain injury: from mechanism to management.Acta neurochirurgica · 2025Review
- Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study.Neurology and therapy · 2025Article
- The Association of Systemic Immune Inflammation Index (SII) and Platelet-to-Lymphocyte Ratio (PLR) on Coagulopathy and Prognosis in Patients with Traumatic Brain Injury.Journal of inflammation research · 2025Article
- Evaluating the Efficacy of Longitudinal Coagulation Biomarkers to Predict in-Hospital Death in Comatose TBI Patients: A Time-Dependent Roc Curve Approach.Medical journal of the Islamic Republic of Iran · 2025Article
- Development and validation of a nomogram-based risk prediction model for unfavorable outcomes in pediatric traumatic brain injury: a retrospective study.Frontiers in pediatrics · 2025Article
- Do admission glucose levels independently predict coagulopathy in multiple trauma patients? A retrospective cohort analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Article
- Cognitive impairment in Chinese traumatic brain injury patients: from challenge to future perspectives.Frontiers in neuroscience · 2024Review
- Incidence, risk factors, and clinical outcomes of acute brain swelling associated with traumatic acute subdural hematoma: a retrospective study utilizing novel diagnostic criteria.Therapeutic advances in neurological disorders · 2024Article
- Malaria-induced Coagulopathy: Complexities and Treatment Challenges in Intracranial Hemorrhage.Annals of neurosciences · 2024Article
- Correlation Between Low Platelet-to-Lymphocyte Ratio and High Mortality Rates in Adult Trauma Patients With Moderate-to-Severe Brain Injuries.Emergency medicine international · 2024Article
- Neutrophil to Lymphocyte Ratio as a Predictor of Postoperative Outcomes in Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Diseases (Basel, Switzerland) · 2023Review
- The trend of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in spontaneous intracerebral hemorrhage and the predictive value of short-term postoperative prognosis in patients.Frontiers in neurology · 2023Article
- Systemic immune inflammation index and peripheral blood carbon dioxide concentration at admission predict poor prognosis in patients with severe traumatic brain injury.Frontiers in immunology · 2022Article
- Abnormal serum Magnesium Level is Associated with the Coagulopathy in Traumatic Brain Injury Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe incidence of coagulopathy after open traumatic brain injury (TBI) is high. Coagulopathy can aggravate intracranial hemorrhage and further increase morbidity and mortality. The purpose of this study was to determine the clinical characteristics of coagulopathy after open TBI and its relationship with the prognosis.
methodsThis study retrospectively evaluated patients with isolated open TBI from December 2018 to December 2020. Coagulopathy was defined as international normalized ratio (INR) > 1.2, activated thromboplastin time (APTT) > 35 s, or platelet count <100,000/μL. We compared the relationship between the clinical, radiological, and laboratory parameters of patients with and without coagulopathy, and the outcome at discharge. Logistic regression analysis was used to evaluate the risk factors associated with coagulopathy. We then compared the effects of treatment with and without TXA in open TBI patients with coagulopathy.
resultsA total of 132 patients were included in the study; 46 patients developed coagulopathy. Patients with coagulopathy had significantly lower platelet levels (170.5 × 10
conclusionsCoagulopathy often occurs after open TBI. Patients with a low GCS score, high NLR, low PLR, and hyperglycemia at admission are at greater risk of coagulopathy, and therefore of poor prognosis. The efficacy of TXA in open TBI patients with coagulopathy is unclear. In addition, these findings demonstrate that PLR may be a novel indicator for predicting coagulopathy.
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