Evidence map›Paper›PMID 35011909›Full record

ArticleJournal of clinical medicine2021

COVID-19 in Elderly Patients Surgically Treated for Lower Limbs Fracture.

Alessandra Colombini, Michele Davide Maria Lombardo, Laura de Girolamo, Elena De Vecchi, Riccardo Giorgino, Giuseppe Maria Peretti, Giuseppe Banfi, Laura Mangiavini

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Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alessandra ColombiniLaboratorio di Biotecnologie Applicate all'Ortopedia, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0002-1800-3424
Michele Davide Maria LombardoResidency Program in Orthopedics and Traumatology, University of Milan, 20122 Milan, Italy.ORCID 0000-0003-0121-2550
Laura de GirolamoLaboratorio di Biotecnologie Applicate all'Ortopedia, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0002-9979-3092
Elena De VecchiLaboratory of Clinical Chemistry and Microbiology, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Riccardo GiorginoResidency Program in Orthopedics and Traumatology, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-1067-7424
Giuseppe Maria PerettiLaboratorio di Biotecnologie Applicate all'Ortopedia, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0001-9341-7187
Giuseppe BanfiLaboratorio di Biotecnologie Applicate all'Ortopedia, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Laura MangiaviniLaboratorio di Biotecnologie Applicate all'Ortopedia, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0003-1892-1249

Funding

Italian Ministry of Health Ricerca Corrente
6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) pandemic outbreak has posed new problems in the context of patients suffering from other diseases. In particular, musculoskeletal sequelae related to the state of debilitation associated with COVID-19 are important to consider in elderly patients undergoing surgery after lower limbs fracture, especially in the post-operative period. The objective of this study was to evaluate whether COVID-19 influenced biochemical parameter, recovery and mortality of surgically treated patients suffering from lower extremity fractures.

methodsLaboratory and clinical data of 30 patients were extrapolated and analyzed in the pre-operative and post-operative periods. Among these patients, 13 had COVID-19 infection (COVID-19 +), whereas 17 had no signs of COVID-19 infections (COVID-19 -). Long-term clinical and functional outcomes were also analyzed.

resultsLower calcium, slightly higher values of CRP and much higher values of CPK and AST were observed pre-operatively in COVID-19 + patients, who also showed higher prevalence of long-term sequelae than COVID-19 - patients.

conclusionsCOVID-19 affects long-term outcome of elderly patients with lower limb fractures in a multifactorial way. First, the virus directly damages the muscle tissue. Secondly, the lung function impairment worsens the overall performance, making rehabilitation more challenging.

Indexed as

clinical biochemistryCOVID-19elderlyfractureslong-term consequenceslower limbsmortalitysurgery

Identifiers

PMID35011909
PMCPMC8745572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.