ArticleJournal of clinical medicine2021
Fecal Calprotectin Is Increased in Stroke.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Correlation of serum calprotectin with outcome of acute cerebral infarction.Open medicine (Warsaw, Poland) · 2025Article
- Fecal calprotectin levels in patients with fibromyalgia: A cross-sectional study.Archives of rheumatology · 2024Article
- Releasing Dynamic of Serum ST2 and Calprotectin in Patients with Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Gut Dysbiosis: A New Avenue for Stroke Prevention and Therapeutics.Biomedicines · 2023Article
- Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recovery.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundWhile there have been major advances in unveiling the mechanisms comprising the ischemic cascade of CNS, stroke continues to be a significant burden. There is a need to extend the focus toward peripheral changes, and the brain-gut axis has recently gained much attention. Our study aimed to evaluate gut inflammation and its association with blood variables in stroke using fecal calprotectin (FC).
methodsFecal samples were obtained from 27 stroke patients and 27 control subjects. FC was quantitatively measured using a commercial ELISA. Laboratory data on the fecal sample collection were also collected, including CBC, ESR, glucose, creatinine, total protein, albumin, transaminases, and CRP.
resultsThere was a significant increase in FC levels in stroke patients compared to the controls. Furthermore, FC in stroke patients was negatively correlated with the Glasgow Coma Scale. Moreover, FC in stroke patients was positively correlated with CRP and negatively correlated with lymphocyte count and albumin.
conclusionsOur findings show that increased FC is associated with consciousness and systemic response in stroke and warrants further studies to elucidate the usefulness of FC in the management of stroke.
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Registered trials
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