Evidence map›Paper›PMID 35011865›Full record

ArticleJournal of clinical medicine2021

Positive ROS (Reactive Oxygen Species) Modulator Engineered Device Support Skin Treatment in Locally Advanced Breast Cancer (LABC) Enhancing Patient Quality of Life.

Donato Casella, Paolo Palumbo, Sara Sandroni, Claudio Caponi, Francesca Littori, Francesca Capuano, Luca Grimaldi, Marco Marcasciano, Roberto Cuomo

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Donato CasellaOncological Breast Surgery, Department of Surgery, Santa Maria Alle Scotte Hospital, 53100 Siena, Italy.
Paolo PalumboCasa di cura Villa Fiorita-Prato, 59100 Prato, Italy.
Sara SandroniSenior Nurse Manager Network Wound Care Azienda USL Toscana Sud Est, 52100 Arezzo, Italy.
Claudio CaponiBreast Unit, Oncology Department, Empoli Hospital, 50053 Empoli, Italy.
Francesca LittoriBreast Unit, Oncology Department, Empoli Hospital, 50053 Empoli, Italy.
Francesca CapuanoOncology Department, 59100 Prato, Italy.
Luca GrimaldiPlastic and Reconstructive Surgery, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy.
Marco MarcascianoOncological Breast Surgery, Department of Surgery, Santa Maria Alle Scotte Hospital, 53100 Siena, Italy.
Roberto CuomoPlastic and Reconstructive Surgery, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-8396-095X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of research in genetic and biochemical fields has made it possible to investigate certain metabolic aspects of the microenvironment of chronic skin lesions, including altered cell signalling, highlighting its importance in determining the blockage of repair processes. The purpose of this prospective observational study is to evaluate the efficacy of a medical device consisting of a polyester scaffold enriched with an oleic matrix with controlled release of ROS in the management of LABC skin lesions. During the period from October 2018 to March 2020, 20 patients with locally advanced breast cancer were enrolled and ten were treated with the devices abovementioned. After 30 days of treatment all patients treated reported a general improvement in local conditions with reduction in ulceration area, exudate and odour. The results suggest that the application of these devices even in particular conditions (healthy and neoplastic tissue) does not lead to the onset of negative effects due to the release of ROS, though their role in tissue repair requires further study to fully understand their potential and increase the fields of application of the device by exploiting its modulation capabilities.

Indexed as

breast cancerexudatepainpolyester scaffoldROSwounds

Identifiers

PMID35011865
PMCPMC8745501

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.