Evidence map›Paper›PMID 35011864›Full record

ArticleJournal of clinical medicine2021

The Role of Factor Xa-Independent Pathway and Anticoagulant Therapies in Cancer-Related Stroke.

Hyung Jun Kim, Jong-Won Chung, Oh Young Bang, Yeon Hee Cho, Yun Jeong Lim, Jaechun Hwang, Woo-Keun Seo, Gyeong-Moon Kim, Hee-Jin Kim, Myung-Ju Ahn

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hyung Jun KimDepartment of Neurology, Seoul Hospital, College of Medicine, Ewha Woman's University, Seoul 07804, Korea.ORCID 0000-0002-7518-9739
Jong-Won ChungDepartment of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.ORCID 0000-0002-9200-8899
Oh Young BangDepartment of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
Yeon Hee ChoTranslational and Stem Cell Research Laboratory on Stroke, Samsung Medical Center, Seoul 06351, Korea.
Yun Jeong LimDepartment of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
Jaechun HwangDepartment of Neurology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu 41404, Korea.ORCID 0000-0002-8917-3439
Woo-Keun SeoDepartment of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.ORCID 0000-0002-4004-8434
Gyeong-Moon KimDepartment of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
Hee-Jin KimDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
Myung-Ju AhnDepartment of Hemato-Oncology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.

Funding

National Research Foundation of Korea 2018R1A2B2003489
6 · The paper itself

Abstract

backgroundThe optimal strategy for stroke prevention in cancer patients is unknown. We compared the underlying mechanisms of coagulopathy and the effects of anticoagulants in patients with active cancer and atrial fibrillation (AF).

methodsWe retrospectively enrolled 46 consecutive patients with embolic stroke of unknown source and active cancer (cancer stroke). We consecutively screened patients with cancer patients without stroke (

resultsIn AF stroke, factor Xa activity and cfDNA and D-dimer levels were decreased by treatment with factor Xa inhibitors. In contrast, in cancer stroke, factor Xa activity was decreased, D-dimer levels were unchanged, and cfDNA levels were increased by treatment with factor Xa inhibitors. In cancer stroke patients treated with enoxaparin, D-dimer levels were decreased (

conclusionThe anticoagulation effects of factor Xa inhibitors differed between cancer stroke and AF stroke.

Indexed as

anticoagulationcancercoagulopathystrokethrombosis

Identifiers

PMID35011864
PMCPMC8745325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.