ArticleJournal of clinical medicine2021
Platelet Defects in Acute Myeloid Leukemia-Potential for Hemorrhagic Events.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Review
- Hijacking the helpers: platelet and neutrophil trafficking in AML and therapeutic exploitation.Experimental hematology & oncology · 2026Review
- Generating unseen diseases patient data using ontology enhanced generative adversarial networks.NPJ digital medicine · 2025Article
- Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia.Veterinary pathology · 2025Article
- Acquired platelet disorders.Frontiers in medicine · 2025Review
- Effects of Hypomethylating Agents on Gene Modulation in the Leukemic Microenvironment and Disease Trajectory in a Mouse Model of AML.bioRxiv : the preprint server for biology · 2024Article
- Accurate identification of locally aneuploid cells by incorporating cytogenetic information in single cell data analysis.Scientific reports · 2024Article
- T-TASBlood transfusion = Trasfusione del sangue · 2024Article
- Global hemostasis assays in acute myeloid leukemia: results of an observational prospective study.Blood transfusion = Trasfusione del sangue · 2024Observational
- Evaluation and validation of the prognostic value of platelet indices in patients with leukemia.Clinical and experimental medicine · 2023Review
- Review
- Platelet derived exosomes disrupt endothelial cell monolayer integrity and enhance vascular inflammation in dengue patients.Frontiers in immunology · 2023Article
- Progress in Hematopoietic Stem Cell Transplantation and Cellular Therapies.Journal of clinical medicine · 2022Article
- An Unusual Case of Effusive-Constrictive Pericarditis in the Intensive Care Unit.CASE (Philadelphia, Pa.) · 2022Article
- Flow cytometry for evaluating platelet immunophenotyping and function in patients with thrombocytopenia.Tzu chi medical journalReview
- High-Risk Bleeding in Acute Myeloid Leukemia: Clinical Presentation, Laboratory Markers, and Mortality Trends.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIn acute myeloid leukemia (AML), extensive bleeding is one of the most frequent causes of death. Impaired activation and aggregation processes were identified in previous studies on platelet behaviour associated with this disease. This study's aim was to examine platelet function in correlation with other haemorrhage risk factors (fever, sepsis, recent bleeding, uraemia, leucocytosis, haematocrit value, treatment). DESIGN AND
methodsThe analysis of platelet surface proteins (Glycoprotein Ib-IX (CD42b, CD42a), Glycoprotein IIb-IIIa (CD41, CD61), RESULTS AND INTERPRETATIONS: Our results show a significant decrease in fluorescence level associated with platelet activation markers (CD63 (14.11% vs. 40.78 %
conclusionThe AML patients present changes in adhesion receptors and activation markers, suggesting a functional defect or denatured intracellular signalling in platelets. The exposed data indicate that flow cytometry can effectively identify multiple functional platelet impairments in AML pathogenesis.
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