ReviewJournal of clinical medicine2021
Non-Surgical Strategies for Assisting Closure of Pharyngocutaneous Fistula after Total Laryngectomy: A Systematic Review of the Literature.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of possible risk factors for pharyngocutaneous fistula after total laryngectomy of laryngeal carcinomas and surgical wound infection: A meta-analysis.International wound journal · 2023Pooled it
- Pharyngeal and Cervical Reconstruction and Fistula Management Following Total Laryngectomy: Contemporary Strategies and Evidence.Life (Basel, Switzerland) · 2026Review
- Article
- Article
- Article
- Effects of Myroxylon pereirae, Phenytoin, and Clinoptilolite After Pharyngocutaneous Fistula: An Experimental Animal Model.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Negative Pressure Tube Drainage for the Management of Pharyngocutaneous Fistulas in Patients Following Total Laryngectomy.Journal of clinical medicine · 2025Article
- Horizontal pharyngeal closure during total laryngectomy reduces rates of pharyngocutaneous fistula.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Emerging Concepts Impacting Head and Neck Cancer Surgery Morbidity.Oncology and therapy · 2023Article
- Improved Early Detection Models of Pharyngocutaneous Fistula after Total Laryngectomy.Journal of clinical medicine · 2023Article
- Negative Pressure Wound Therapy in the Head and Neck: A Summary of Uses and Application Techniques.Seminars in plastic surgery · 2023Review
- The Management of Salivary Fistulas.Seminars in plastic surgery · 2023Review
- Meta-analysis of risk factors associated with pharyngocutaneous fistulas following total laryngectomy.American journal of translational research · 2023Review
- Salvage Partial Laryngectomy after Failed Radiotherapy: Oncological and Functional Outcomes.Journal of clinical medicine · 2022Article
- The Many Faces of Head and Neck Surgery in 2022 and Looking Ahead!Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPharyngocutaneous fistula (PCF) is a frequent complication after total laryngectomy, with an incidence of up to 65%. Many conservative or invasive approaches are available and the choice among them is usually made on a case-by-case basis. The aim of the present review is to critically summarize the available evidence of the effectiveness of the non-surgical management of PCF.
methodsA systematic review and a meta-analysis of the literature were conducted, according to the PRISMA guidelines. Studies investigating botulinum toxin therapy, scopolamine transdermal patch, hyperbaric oxygen therapy (HBOT), and negative pressure wound therapy (NPWT) were assessed. Complete fistula closure after the initiation of non-surgical treatment was the main outcome.
resultsAfter the application of selection criteria, a total of seven articles and 27 patients were included in the present review. All the eligible studies were descriptive case series, while only one article used a standard group as a comparison. The mean age was 63.3 and 14 patients (51.9%) had previously received RT. The reported comorbidities were diabetes, ischemic heart disease, hypertension, dyslipidemia, COPD, and atrial fibrillation. With a mean healing time of 25.0 days, the overall success rate was 92.6%.
conclusionsNon-surgical treatment of PCF is only based on the experience of small series. Although success rates seem promising, the absence of properly designed comparative studies does not allow us, at present, to identify ideal candidates for these non-invasive management strategies for PCF.
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