Evidence map›Paper›PMID 35011838›Full record

ArticleJournal of clinical medicine2021

Effects of Resistance Training Intervention along with Leucine-Enriched Whey Protein Supplementation on Sarcopenia and Frailty in Post-Hospitalized Older Adults: Preliminary Findings of a Randomized Controlled Trial.

Maria Amasene, Cristina Cadenas-Sanchez, Iñaki Echeverria, Begoña Sanz, Cristina Alonso, Ignacio Tobalina, Jon Irazusta, Idoia Labayen, Ariadna Besga

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03815201 (Effects of a Combined Physical Training and Protein Supplementation Intervention on Muscle Mass, Functional and Cognitive Performance, and Health-related Quality of Life in the Elderly), which is not on this map. Cited by 14 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03815201 naunknown statusnot on this map

Effects of a Combined Physical Training and Protein Supplementation Intervention on Muscle Mass, Functional and Cognitive Performance, and Health-related Quality of Life in the Elderly: a Randomized Controlled Trial.

TypeinterventionalSponsorBasque Health ServiceRan2017 to 2019Enrolled41ConditionsSarcopeniaArmsGroup 2, Group 1
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria AmaseneDepartment of Pharmacy and Food Science, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0002-3606-3834
Cristina Cadenas-SanchezInstitute for Innovation & Sustainable Development in Food Chain (IS-FOOD), Public University of Navarra, 31006 Pamplona, Spain.ORCID 0000-0002-4513-9108
Iñaki EcheverriaDepartment of Physiology, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.ORCID 0000-0002-1042-4494
Begoña SanzDepartment of Physiology, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.ORCID 0000-0002-6354-6401
Cristina AlonsoPhysical Rehabilitation Service, Araba University Hospital, Bioaraba Research Institute, OSI Araba, 01004 Vitoria-Gasteiz, Spain.
Ignacio TobalinaDepartment of Nuclear Medicine, Araba University Hospital, 01004 Vitoria-Gasteiz, Spain.
Jon IrazustaDepartment of Physiology, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.ORCID 0000-0002-6763-8602
Idoia LabayenInstitute for Innovation & Sustainable Development in Food Chain (IS-FOOD), Public University of Navarra, 31006 Pamplona, Spain.ORCID 0000-0002-4334-3287
Ariadna BesgaDepartment of Internal Medicine, Araba University Hospital, Bioaraba Research Institute, OSI Araba, CIBERSAM, University of the Basque Country UPV/EHU, 01004 Vitoria-Gasteiz, Spain.

Funding

Basque Government 2016111138University of the Basque Country PIF17/186University of the Basque Country PIFBUR16/07
6 · The paper itself

Abstract

Resistance training and protein supplementation are expected to exert the greatest effect in counteracting muscle-wasting conditions. Myokines might play a key role, but this remains to be elucidated. The aim of this study (NCT03815201) was to examine the effects of a resistance training program with post-exercise leucine-enriched protein supplementation on sarcopenia and frailty status and on the plasma myokine concentrations of post-hospitalized older adults. A total of 41 participants were included in this 12-week resistance training intervention and randomized either to the placebo group or the protein group. Sarcopenia, frailty, body composition and blood-based myokines were measured at baseline and after 12 weeks. Both groups improved in terms of physical performance (

Indexed as

elderlyhospitalleucinemuscle massmuscle wastingmyokinemyostatinproteinstrength trainingwhey protein

Identifiers

PMID35011838
PMCPMC8745511

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.