Evidence map›Paper›PMID 35011770›Full record

ArticleJournal of clinical medicine2021

Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Greatly Improved Fatigue Symptoms When Treated with Oxygen-Ozone Autohemotherapy.

Umberto Tirelli, Marianno Franzini, Luigi Valdenassi, Sergio Pandolfi, Massimiliano Berretta, Giovanni Ricevuti, Salvatore Chirumbolo

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Recent research in myalgic encephalomyelitis/chronic fatigue syndrome: an evidence map.Health technology assessment (Winchester, England) · 2025
    Pooled it
  2. Article
  3. Article
  4. Ozone therapy in musculoskeletal medicine: a comprehensive review.European journal of medical research · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Umberto TirelliTirelli Medical Group, 33170 Pordenone, Italy.
Marianno FranziniItalian Society of Oxygen Ozone Therapy (SIOOT), University of Pavia, 27100 Pavia, Italy.
Luigi ValdenassiItalian Society of Oxygen Ozone Therapy (SIOOT), University of Pavia, 27100 Pavia, Italy.
Sergio PandolfiItalian Society of Oxygen Ozone Therapy (SIOOT), University of Pavia, 27100 Pavia, Italy.
Massimiliano BerrettaDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.ORCID 0000-0002-9837-9148
Giovanni RicevutiItalian Society of Oxygen Ozone Therapy (SIOOT), University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-3422-2747
Salvatore ChirumboloDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.ORCID 0000-0003-1789-8307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic syndrome characterized by fatigue as its major and most outstanding symptom. Previous evidence has supported the ability of ozone to relief ME/CFS related fatigue in affected patients (2) Methods: A number of 200 ME/CFS previously diagnosed patients, (mean age 33 ± 13 SD years) were consecutively treated with oxygen-ozone autohemotherapy (O

Indexed as

clinical trialfatigueME/CFSoxygen-ozone therapyozone

Identifiers

PMID35011770
PMCPMC8745272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.