Evidence map›Paper›PMID 35011763›Full record

ArticleJournal of clinical medicine2021

Clinical, Histological, and Genetic Features of 25 Patients with Autosomal Dominant Progressive External Ophthalmoplegia (ad-PEO)/PEO-Plus Due to

Laura Bermejo-Guerrero, Carlos Pablo de Fuenmayor-Fernández de la Hoz, Pablo Serrano-Lorenzo, Alberto Blázquez-Encinar, Gerardo Gutiérrez-Gutiérrez, Laura Martínez-Vicente, Lucía Galán-Dávila, Jorge García-García, Joaquín Arenas, Nuria Muelas and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05653544 (Natural History and Longitudinal Clinical Assessments in a Spanish Cohort of Primary Mitochondrial Myopathies), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05653544 recruitingnot on this mapstarted 2023, after this paper: background citation

Natural History and Longitudinal Clinical Assessments in a Spanish Cohort of Primary Mitochondrial Myopathies

Typeobservational_patient_registrySponsorCristina Domínguez GonzálezRan2023 to 2026Enrolled150ConditionsPrimary Mitochondrial Myopathies
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Myopathies in clinical care: a focus on treatable causes.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. The First HeterozygousBiomolecules · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Laura Bermejo-GuerreroNeuromuscular Unit, Department of Neurology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.ORCID 0000-0002-8349-715X
Carlos Pablo de Fuenmayor-Fernández de la HozNeuromuscular Unit, Department of Neurology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Pablo Serrano-LorenzoHospital 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain.ORCID 0000-0002-5661-7574
Alberto Blázquez-EncinarHospital 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain.ORCID 0000-0002-6479-3615
Gerardo Gutiérrez-GutiérrezDepartment of Neurology, Hospital Universitario Infanta Sofía, 28703 Madrid, Spain.ORCID 0000-0003-1391-754X
Laura Martínez-VicenteDepartment of Neurology, Hospital Universitario Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0003-0622-7380
Lucía Galán-DávilaDepartment of Neurology, Hospital Universitario Clínico San Carlos, 28040 Madrid, Spain.
Jorge García-GarcíaDepartment of Neurology, Complejo Hospitalario Universitario de Albacete, 02006 Albacete, Spain.
Joaquín ArenasHospital 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain.
Nuria MuelasBiomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Aurelio Hernández-LaínHospital 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain.
Cristina Domínguez-GonzálezNeuromuscular Unit, Department of Neurology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.ORCID 0000-0001-5151-988X
Miguel A MartínHospital 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain.ORCID 0000-0003-4741-772X

Funding

Instituto de Salud Carlos III PI18/01374Ministry of Science and Innovation, Madrid, Spain PMP15_00025
6 · The paper itself

Abstract

Autosomal dominant mutations in the

Indexed as

mitochondrial dysfunctionmtDNA maintenance defectsprogressive external ophthalmoplegiaTWNK gene

Identifiers

PMID35011763
PMCPMC8745442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.