Evidence map›Paper›PMID 35011738›Full record

ArticleCells2022

Targeting PGM3 as a Novel Therapeutic Strategy in

Hyunmin Lee, Feng Cai, Neil Kelekar, Nipun K Velupally, Jiyeon Kim

Abstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyunmin LeeDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
Feng CaiChildren's Medical Center Research Institute, UT-Southwestern Medical Center, Dallas, TX 75390, USA.
Neil KelekarDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
Nipun K VelupallyDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
Jiyeon KimDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.

Funding

Targeting altered nitrogen metabolism in an aggressive subset of human lung canceK22CA226676 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KIM, JIYEON · 2019 to 2021
$591k
American Cancer Society RSG-21-153-01-CCBAmerican Lung Association IA-828202American Lung Association LCD-614827NCI NIH HHS 1K22CA226676-01A1V Foundation for Cancer Research V2019-022
6 · The paper itself

Abstract

In non-small-cell lung cancer (NSCLC), concurrent mutations in the oncogene

Indexed as

Molecular Targeted TherapyAMP-Activated Protein Kinase KinasesAnimalsBiosynthetic PathwaysCell Line, TumorCell ProliferationCell SurvivalGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)GlycosylationHexosaminesHumansLung NeoplasmsMicePhosphoglucomutaseProto-Oncogene Proteins p21(ras)AMP-Activated Protein Kinase KinasesGFPT2 protein, humanGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)HexosaminesKRAS protein, humanPGM3 protein, humanPhosphoglucomutaseProto-Oncogene Proteins p21(ras)STK11 protein, humancancer metabolismglycosylationKRAS and LKB1 co-mutationsmetabolic vulnerabilitynon-small cell lung cancerO-GlcNAcylationthe hexosamine biosynthesis pathway

Identifiers

PMID35011738
PMCPMC8750012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.