Evidence map›Paper›PMID 35011674›Full record

ArticleCells2021

Impaired Glucocorticoid Receptor Signaling Aggravates Lung Injury after Hemorrhagic Shock.

Jonathan M Preuss, Ute Burret, Michael Gröger, Sandra Kress, Angelika Scheuerle, Peter Möller, Jan P Tuckermann, Martin Wepler, Sabine Vettorazzi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jonathan M PreussInstitute of Comparative Molecular Endocrinology (CME), Ulm University, 89081 Ulm, Germany.
Ute BurretInstitute of Comparative Molecular Endocrinology (CME), Ulm University, 89081 Ulm, Germany.
Michael GrögerInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.
Sandra KressInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.
Angelika ScheuerleInstitute of Pathology, University Hospital, 89081 Ulm, Germany.
Peter MöllerInstitute of Pathology, University Hospital, 89081 Ulm, Germany.
Jan P TuckermannInstitute of Comparative Molecular Endocrinology (CME), Ulm University, 89081 Ulm, Germany.
Martin WeplerInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.
Sabine VettorazziInstitute of Comparative Molecular Endocrinology (CME), Ulm University, 89081 Ulm, Germany.ORCID 0000-0001-8667-9488
Universität Ulm · DEUniversity Hospital Ulm · DE

Funding

Deutsche Forschungsgemeinschaft Project-ID 251293561 - SFB 1149
6 · The paper itself

Abstract

We previously showed that attenuated lung injury after hemorrhagic shock (HS) coincided with enhanced levels of the glucocorticoid (GC) receptor (GR) in lung tissue of swine. Here, we investigated the effects of impaired GR signaling on the lung during resuscitated HS using a dysfunctional GR mouse model (GR

Indexed as

AnimalsDisease Models, AnimalHumansLung InjuryMiceReceptors, GlucocorticoidShock, HemorrhagicSignal TransductionReceptors, Glucocorticoidglucocorticoid receptorhemorrhagic shockhomodimerresuscitation

Identifiers

PMID35011674
PMCPMC8750862
OpenAlexW4205811553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.