Evidence map›Paper›PMID 35011649›Full record

ArticleCells2021

The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells.

Chiara Maria Giulia De Luca, Alessandra Consonni, Federico Angelo Cazzaniga, Edoardo Bistaffa, Giuseppe Bufano, Giorgia Quitarrini, Luigi Celauro, Giuseppe Legname, Roberto Eleopra, Fulvio Baggi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. The Progress of Active Immunotherapy for Parkinson's Disease.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Inflammation in multiple system atrophy.Frontiers in immunology · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Chiara Maria Giulia De LucaDivision of Neurology 5, Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0002-6233-8272
Alessandra ConsonniDivision of Neurology 4, Neuroimmunology and Neuromuscular Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Federico Angelo CazzanigaDivision of Neurology 5, Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Edoardo BistaffaDivision of Neurology 5, Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Giuseppe BufanoDivision of Neurology 5, Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0001-5768-4536
Giorgia QuitarriniDivision of Neurology 5, Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Luigi CelauroLaboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore Di Studi Avanzati (SISSA), 34136 Trieste, Italy.ORCID 0000-0002-5731-3257
Giuseppe LegnameLaboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore Di Studi Avanzati (SISSA), 34136 Trieste, Italy.ORCID 0000-0003-0716-4393
Roberto EleopraDivision of Neurology 1, Parkinson and Movement Disorders, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Fulvio BaggiDivision of Neurology 4, Neuroimmunology and Neuromuscular Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0002-4618-0102
Giorgio GiacconeDivision of Neurology 5, Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Fabio ModaDivision of Neurology 5, Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0002-2820-9880
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITScuola Internazionale Superiore di Studi Avanzati · IT

Funding

Associazione Italiana Encefalopatie da Prioni (AIEnP)Ministero della Salute Current Research
6 · The paper itself

Abstract

Parkinson's disease (PD) and multiple system atrophy (MSA) are caused by two distinct strains of disease-associated α-synuclein (αSyn

Indexed as

alpha-SynucleinCell DifferentiationCell Line, TumorHumansInflammationMultiple System AtrophyNeuroblastomaOlfactory MucosaParkinson DiseaseProtein AggregatesRecombinant Proteinsalpha-SynucleinProtein AggregatesRecombinant Proteinsmultiple system atrophyolfactory mucosaParkinson’s diseaseRT-QuICstrainsα-synuclein

Identifiers

PMID35011649
PMCPMC8750063
OpenAlexW4200072129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.