Evidence map›Paper›PMID 35011643›Full record

ArticleCells2021

Role of Myeloid Tet Methylcytosine Dioxygenase 2 in Pulmonary and Peritoneal Inflammation Induced by Lipopolysaccharide and Peritonitis Induced by

Wanhai Qin, Xanthe Brands, Hisatake Matsumoto, Joe M Butler, Cornelis Van't Veer, Alex F de Vos, Joris J T H Roelofs, Brendon P Scicluna, Tom van der Poll

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Biology · 2026
    Article
  3. Article
  4. Article
  5. Observational
  6. TET3-overexpressing macrophages promote endometriosis.The Journal of clinical investigation · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wanhai QinCenter of Experimental & Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-7776-5007
Xanthe BrandsCenter of Experimental & Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Hisatake MatsumotoCenter of Experimental & Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Joe M ButlerCenter of Experimental & Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Cornelis Van't VeerCenter of Experimental & Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Alex F de VosCenter of Experimental & Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Joris J T H RoelofsDepartment of Pathology, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Brendon P SciclunaCenter of Experimental & Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Tom van der PollCenter of Experimental & Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Amsterdam UMC Location University of Amsterdam · NL

Funding

China Scholarship Council 201606170115ZonMw 50-53000-98-139
6 · The paper itself

Abstract

Tet methylcytosine dioxygenase 2 (Tet2) mediates demethylation of DNA. We here sought to determine the expression and function of Tet2 in macrophages upon exposure to lipopolysaccharide (LPS), and in the host response to LPS induced lung and peritoneal inflammation, and during

Indexed as

AnimalsAnti-Bacterial AgentsChemokine CXCL1DioxygenasesDNA-Binding ProteinsEscherichia coliGene Expression RegulationHEK293 CellsHistone DeacetylasesHumansInflammationInterleukin-1betaInterleukin-6LigandsLipopolysaccharidesLungAnti-Bacterial AgentsChemokine CXCL1DioxygenasesDNA-Binding ProteinsHistone DeacetylasesInterleukin-1betaInterleukin-6LigandsLipopolysaccharidesNod2 protein, mouseNod2 Signaling Adaptor ProteinTET2 protein, humanTet2 protein, mouseToll-Like ReceptorsE. coliinfectioninflammationmacrophagesTET2

Identifiers

PMID35011643
PMCPMC8750455
OpenAlexW4200500016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.