Evidence map›Paper›PMID 35011630›Full record

ArticleCells2021

High Throughput Small Molecule Screen for Reactivation of

Jack F V Hunt, Meng Li, Ryan Risgaard, Gene E Ananiev, Scott Wildman, Fan Zhang, Tim S Bugni, Xinyu Zhao, Anita Bhattacharyya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jack F V HuntWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-5719-9028
Meng LiWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Ryan RisgaardWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-6240-9843
Gene E AnanievCarbone Cancer Center Drug Discovery Core, University of Wisconsin-Madison, Madison, WI 53705, USA.
Scott WildmanCarbone Cancer Center Drug Discovery Core, University of Wisconsin-Madison, Madison, WI 53705, USA.
Fan ZhangSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.
Tim S BugniSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-4502-3084
Xinyu ZhaoWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-5128-4424
Anita BhattacharyyaWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-0360-7145
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
Translational Regulation of Adult Neural Stem CellsR01MH078972 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2007 to 2016
$4.3M
The Role of MDM2 in FMRP regulation of neuronal developmentR01MH116582 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2018 to 2022
$2.2M
The role of RNA binding protein in FXR1P in interneuronsR01MH118827 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2019 to 2023
$2.2M
Integration of Experience-Induced Gene Expression and Circuit FunctionsR01NS105200 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI JACKSON, MEYER B., ZHAO, XINYU · 2018 to 2022
$2.0M
Identification of FMRP targets in human cortical neuronsR21NS105339 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI BHATTACHARYYA, ANITA, ZHAO, XINYU · 2018 to 2019
$421k
Defining interneuron deficits in Down syndrome brain.R03HD083538 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BHATTACHARYYA, ANITA · 2016 to 2017
$160k
National Institute of Health R21HD08528NCI NIH HHS P30 CA014520NICHD NIH HHS P50 HD105353NICHD NIH HHS R03 HD083538NICHD NIH HHS U54 HD090256NIGMS NIH HHS T32 GM140935NIMH NIH HHS R01 MH078972NIMH NIH HHS R01 MH116582NIMH NIH HHS R01 MH118827NINDS NIH HHS R01 NS105200NINDS NIH HHS R21 NS105339
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is the most common inherited cause of autism and intellectual disability. The majority of FXS cases are caused by transcriptional repression of the

Indexed as

High-Throughput Screening AssaysDrug Evaluation, PreclinicalFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeGenetic LociHumansNeural Stem CellsNeuronsReproducibility of ResultsSmall Molecule LibrariesFragile X Messenger Ribonucleoprotein 1Small Molecule Librariesdrug screenFMR1fragile X syndromegene reactivationhuman pluripotent stem cellssmall molecule

Identifiers

PMID35011630
PMCPMC8750025
OpenAlexW4200333545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.