Evidence map›Paper›PMID 35011602›Full record

ArticleCells2021

Up-Regulation of Fibroblast Growth Factor 23 Gene Expression in UMR106 Osteoblast-like Cells with Reduced Viability.

Sina Münz, Martina Feger, Bayram Edemir, Michael Föller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sina MünzDepartment of Physiology, University of Hohenheim, 70599 Stuttgart, Germany.
Martina FegerDepartment of Physiology, University of Hohenheim, 70599 Stuttgart, Germany.
Bayram EdemirDepartment of Hematology and Oncology, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany.
Michael FöllerDepartment of Physiology, University of Hohenheim, 70599 Stuttgart, Germany.
University of Hohenheim · DEMartin Luther University Halle-Wittenberg · DE

Funding

Deutsche Forschungsgemeinschaft (Fo 695/6-1)
6 · The paper itself

Abstract

Fibroblast growth factor 23 (FGF23) controls vitamin D and phosphate homeostasis in the kidney and has additional paracrine effects elsewhere. As a biomarker, its plasma concentration is associated with progression of inflammatory, renal, and cardiovascular diseases. Major stimuli of FGF23 synthesis include active vitamin D and inflammation. Antineoplastic chemotherapy treats cancer by inducing cellular damage ultimately favoring cell death (apoptosis and necrosis) and causing inflammation. Our study explored whether chemotherapeutics and other apoptosis inducers impact on

Indexed as

AnimalsCell LineCell SurvivalCisplatinDoxorubicinFibroblast Growth Factor-23HydrazonesInterleukin-6NF-kappa BOsteoblastsPiperazinesRatsSignal TransductionUp-Regulation(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazineCisplatinDoxorubicinFibroblast Growth Factor-23HydrazonesInterleukin-6NF-kappa BPiperazines1,25(OH)2D3apoptosiscisplatininflammationklotho

Identifiers

PMID35011602
PMCPMC8750768
OpenAlexW4200474091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.