Evidence map›Paper›PMID 35011586›Full record

ArticleCells2021

Pluripotent Stem Cell-Derived Hepatocytes Inhibit T Cell Proliferation

Marco Romano, Raul Elgueta, Daniel McCluskey, Ana Maria Ortega-Prieto, Emilie Stolarczyk, Francesco Dazzi, Baltasar Lucendo-Villarin, Jose Meseguer-Ripolles, James Williams, Giorgia Fanelli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Tryptophan's Journey Through Pregnancy: The Role of Serotonin.International journal of tryptophan research : IJTR · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Marco RomanoPeter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, London SE1 9RT, UK.ORCID 0000-0001-6089-5828
Raul ElguetaPeter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, London SE1 9RT, UK.
Daniel McCluskeyPeter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, London SE1 9RT, UK.
Ana Maria Ortega-PrietoSection of Virology, Faculty of Medicine, St Mary's Campus, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0002-9023-0103
Emilie StolarczykDivision for Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Hammersmith Campus, Imperial College London, London SW7 2AZ, UK.
Francesco DazziDivision of Cancer Studies, Rayne Institute, King's College London, London SE1 9RT, UK.ORCID 0000-0003-2407-236X
Baltasar Lucendo-VillarinCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK.
Jose Meseguer-RipollesCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK.
James WilliamsCentre for Stem Cells & Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.ORCID 0000-0003-3206-7851
Giorgia FanelliPeter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, London SE1 9RT, UK.
David C HayCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK.ORCID 0000-0002-7593-5973
Fiona M WattCentre for Stem Cells & Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Giovanna LombardiPeter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, London SE1 9RT, UK.
King's College London · GBMRC Centre for Regenerative Medicine · GBGuy's Hospital · GBHammersmith Hospital · GBImperial College London · GB

Funding

British Heart Foundation RG/13/12/30395Chief Scientist Office TCS/16/37Chief Scientist Office [UK] TCS 16/37Medical Research Council MR/L022699/1Medical Research Council MR/S020934/1
6 · The paper itself

Abstract

Regenerative medicine aims to replace damaged tissues by stimulating endogenous tissue repair or by transplanting autologous or allogeneic cells. Due to their capacity to produce unlimited numbers of cells of a given cell type, pluripotent stem cells, whether of embryonic origin or induced via the reprogramming of somatic cells, are of considerable therapeutic interest in the regenerative medicine field. However, regardless of the cell type, host immune responses present a barrier to success. The aim of this study was to investigate

Indexed as

Allogeneic CellsCell ProliferationHepatocytesHumansImmunologic FactorsImmunophenotypingIndoleamine-Pyrrole 2,3,-DioxygenaseInduced Pluripotent Stem CellsLymphocyte ActivationReceptors, Antigen, T-CellT-LymphocytesTryptophanIDO1 protein, humanImmunologic FactorsIndoleamine-Pyrrole 2,3,-DioxygenaseReceptors, Antigen, T-CellTryptophanin vitro studiesiPSC-derived hepatocyte-like cellsregenerative medicineT cell activation

Identifiers

PMID35011586
PMCPMC8750013
OpenAlexW4200486534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.