Evidence map›Paper›PMID 35011569›Full record

ArticleCells2021

The Cross-Talk between Myeloid and Mesenchymal Stem Cells of Human Bone Marrow Represents a Biomarker of Aging That Regulates Immune Response and Bone Reabsorption.

Maria Elisa Perico, Tommaso Maluta, Giamaica Conti, Antonio Vella, Lisa Provezza, Tiziana Cestari, Giulia De Cao, Lydia Segalla, Cristina Tecchio, Fabio Benedetti and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Maria Elisa PericoSection of Immunology, Department of Medicine, University of Verona, Policlinico GB Rossi, Piazzale L.A. Scuro 10, 37134 Verona, Italy.ORCID 0000-0001-5047-371X
Tommaso MalutaOrthopedic and Traumatology Clinic, Department of Surgery, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-7419-0546
Giamaica ContiSection of Anatomy and Histology, Department of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.
Antonio VellaSection of Immunology, Department of Medicine, University of Verona, Policlinico GB Rossi, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Lisa ProvezzaSection of Immunology, Department of Medicine, University of Verona, Policlinico GB Rossi, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Tiziana CestariSection of Immunology, Department of Medicine, University of Verona, Policlinico GB Rossi, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Giulia De CaoOrthopedic and Traumatology Clinic, Department of Surgery, University of Verona, 37134 Verona, Italy.
Lydia SegallaSection of Anatomy and Histology, Department of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.
Cristina TecchioSection of Hematology and Bone Marrow Transplant Unit, Department of Medicine, University of Verona, 37134 Verona, Italy.
Fabio BenedettiSection of Hematology and Bone Marrow Transplant Unit, Department of Medicine, University of Verona, 37134 Verona, Italy.
Francesco SantiniSection of Cardio Surgery, Department of Surgery, University of Verona, 37134 Verona, Italy.
Vincenzo BronteSection of Immunology, Department of Medicine, University of Verona, Policlinico GB Rossi, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Bruno MagnanOrthopedic and Traumatology Clinic, Department of Surgery, University of Verona, 37134 Verona, Italy.
Andrea SbarbatiSection of Anatomy and Histology, Department of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.
Dunia RamarliSection of Immunology, Azienda Ospedaliera Universitaria Integrata, 37134 Verona, Italy.
University of Verona · ITAzienda Ospedaliera Universitaria Integrata Verona · IT

Funding

AIRC 5 x 1000 grant to Vincenzo Bronte 12182FUR Sbarbati NA
6 · The paper itself

Abstract

One of the mechanisms that characterizes the aging process of different organs is the accumulation of fat. Different authors have demonstrated that adipose tissue replaces the loss of other cell types, deriving from mesenchymal cells. During aging, there is substitution or trans-differentiation of mesenchymal cells with other cells having the same embryological origin. Newly formed adipocytes were also observed in the trabecular matrix of elderly people's bones, associated with myeloid cells. In this study, we have investigated the relationship between immature myeloid-derived suppressor cells (I-MDSCs) and mesenchymal stem cells (MSCs) in bone marrow (BM) samples harvested from 57 patients subjected to different orthopedic surgeries. Patients aged from 18 to 92 years were considered in order to compare the cellular composition of bone marrow of young and elderly people, considered a biomarker of immunity, inflammation, and bone preservation. The I-MDSC percentage was stable during aging, but in elderly people, it was possible to observe a strong basal immunosuppression of autologous and heterologous T cells' proliferation. We hypothesized that this pattern observed in elders depends on the progressive accumulation in the BM of activating stimuli, including cell-cell contact, or the production of different cytokines and proteins that induce the differentiation of bone marrow mesenchymal stem cells in adipocytes. The collected data provided underline the importance of specific biomarkers of aging that promote a reduction in immune response and incremented inflammatory pathways, leading to bone reabsorption in elderly people.

Indexed as

ImmunityAdipocytesAdipogenesisAdolescentAdultAgedAged, 80 and overAgingBiomarkersBone and BonesBone Marrow CellsCell DifferentiationCytokinesFemaleGene Expression RegulationHumansBiomarkersCytokinesInterleukin-6adipogenesisagingbone marrowIL-6suppression

Identifiers

PMID35011569
PMCPMC8750773
OpenAlexW4200560178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.