ArticleCells2021
Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.
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Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
4.1field-weighted citation impact, top 4% of its field
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49 citing papers in PubMed, 64 citations in OpenAlex.
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- The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy.BMC medicine · 2025Review
- Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: Focus on PPARs, LXRs, and PCSK9.Atherosclerosis plus · 2025Review
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- TRIB3 is a biomarker of poor prognosis in laryngeal squamous cell carcinoma and may affect tumor development through PI3K / AKT / mTOR pathway.Clinics (Sao Paulo, Brazil) · 2025Article
- Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy.International journal of obesity (2005) · 2024Article
- Time-Restricted Feeding Attenuates Adipose Tissue Inflammation and Fibrosis in Mice Under Chronic Light Exposure.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 4 countries.
Terry D HindsDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.ORCID 0000-0002-7599-1529
Zachary A KippDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.
Mei XuDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.
Frederique B YiannikourisDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.
Andrew J MorrisDivision of Cardiovascular Medicine, College of Medicine, University of Kentucky, Lexington, KY 40508, USA.ORCID 0000-0003-1910-4865
Donald F StecSmall Molecule NMR Facility Core, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA.
Walter WahliLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, Singapore 308232, Singapore.ORCID 0000-0002-5966-9089
David E StecDepartment of Physiology & Biophysics, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0001-8359-4008
University of Kentucky · USVanderbilt University · USUniversité Toulouse III - Paul Sabatier · FR
Funding
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4MThe role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI KATZ, WENDY S · 2012 to 2017
$13.7MPilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7MNovel Liver Signaling Pathways Controlling AdiposityR01DK121797 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HINDS, TERRY D · 2020 to 2024
$2.2MIntegrative Role of Bilirubin on ObesityR01DK121748 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI STEC, DAVID E · 2020 to 2023
$2.0MAntioxidant-PPARalpha interaction and hypertensionK01HL125445 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HINDS, TERRY D · 2015 to 2019
$779kBLRD VA I01 BX005637National Heart Lung and Blood Institute P01 HL05197-11NHLBI NIH HHS K01 HL125445NIDDK NIH HHS 1R01DK121797-01A1NIDDK NIH HHS 1R01DK126884-01A1NIDDK NIH HHS R01 DK121748NIDDK NIH HHS R01 DK121797NIGMS NIH HHS P20 GM103527NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P30 GM127211
Abstract
The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it transactivates genes for β-oxidation. Contrarily, the function of PPARα in extrahepatic tissues is less known. Therefore, we established the first adipose-specific PPARα knockout (
Indexed as
Cell PolarityLipogenesisAdipocytesAdipose Tissue, WhiteAdiposityAmino AcidsAnimalsBiomarkersBody WeightCholesterolDiet, High-FatFemaleInflammationLipidomicsMacrophagesMaleAmino AcidsBiomarkersCholesterolPAS domain kinasesPPAR alphaProtein Serine-Threonine KinasesSterol Regulatory Element Binding Protein 1adipocyteadipogenesischolesterol estersFASfatty acid synthaseinflammationlipid signalingobesitySCD1sexual dimorphism
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.