ArticleMolecules (Basel, Switzerland)2022
Antibacterial Activity of Pharmaceutical-Grade Rose Bengal: An Application of a Synthetic Dye in Antibacterial Therapies.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Lectin-Rose Bengal Conjugates for Targeted Photodynamic Inactivation of Pathogenic Bacteria.International journal of molecular sciences · 2026Article
- Stable, bioactive hydrogel coating on silicone surfaces for non-invasive decontamination via photochemical treatment.Bioactive materials · 2025Article
- Development of Tunable Rose Bengal-Based nanoGUMBOS as Potential Selective Chemotherapeutic Agents.ACS omega · 2025Article
- Rose Bengal Conjugated to Lectins for Targeted Antibacterial Photodynamic Treatment.Molecules (Basel, Switzerland) · 2025Article
- Rose Bengal-Chitosan Nanocomposites for Oral Administration.Nanomaterials (Basel, Switzerland) · 2025Article
- Exploring Gluconamide-Modified Silica Nanoparticles of Different Sizes as Effective Carriers for Antimicrobial Photodynamic Therapy.Nanomaterials (Basel, Switzerland) · 2024Article
- Antibacterial Properties of Rose Bengal Conjugated to Hyaluronic Acid.International journal of molecular sciences · 2024Article
- Effects of Antimicrobial Photosensitizers of Photodynamic Therapy (PDT) to Treat Periodontitis.Current pharmaceutical biotechnology · 2024Review
- Managing Corneal Infections: Out with the old, in with the new?Antibiotics (Basel, Switzerland) · 2023Review
- Antibacterial effect of rose bengal against colistin-resistant gram-negative bacteria.The Journal of antibiotics · 2023Article
- Staphylococcus aureus from Atopic Dermatitis Patients: Its Genetic Structure and Susceptibility to Phototreatment.Microbiology spectrum · 2023Article
- Antimicrobial Photodynamic Inactivation: An Alternative for Group BAntioxidants (Basel, Switzerland) · 2023Article
- Fluorescence-Coupled Techniques for Determining Rose Bengal in Dermatological Formulations and Their Application to Ex Vivo Skin Deposition Studies.Pharmaceutics · 2023Article
- Assessment of Dye-Absorbed Eggshell Membrane Composites as Solid Polymer Electrolyte of Fuel Cells.Membranes · 2023Article
- Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment.Polymers · 2023Article
- Novel Utilization of Therapeutic Coatings Based on Infiltrated Encapsulated Rose Bengal Microspheres in Porous Titanium for Implant Applications.Pharmaceutics · 2022Article
- Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rose bengal has been used in the diagnosis of ophthalmic disorders and liver function, and has been studied for the treatment of solid tumor cancers. To date, the antibacterial activity of rose bengal has been sporadically reported; however, these data have been generated with a commercial grade of rose bengal, which contains major uncontrolled impurities generated by the manufacturing process (80-95% dye content). A high-purity form of rose bengal formulation (HP-RBf, >99.5% dye content) kills a battery of Gram-positive bacteria, including drug-resistant strains at low concentrations (0.01-3.13 μg/mL) under fluorescent, LED, and natural light in a few minutes. Significantly, HP-RBf effectively eradicates Gram-positive bacterial biofilms. The frequency that Gram-positive bacteria spontaneously developed resistance to HP-RB is extremely low (less than 1 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.