Evidence map›Paper›PMID 35011550›Full record

ArticleMolecules (Basel, Switzerland)2022

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-

Farhana Islam, Arpit Doshi, Andrew J Robles, Tasdique M Quadery, Xin Zhang, Xilin Zhou, Ernest Hamel, Susan L Mooberry, Aleem Gangjee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. 2-Alkyl-Substituted-4-Amino-Thieno[2,3-Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Farhana IslamDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Arpit DoshiDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Andrew J RoblesDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Tasdique M QuaderyDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Xin ZhangDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Xilin ZhouDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Ernest HamelMolecular Pharmacology Branch, Developmental Therapeutics Program, Frederick National Laboratory for Cancer Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Susan L MooberryDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.ORCID 0000-0001-8575-2516
Aleem GangjeeDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Duquesne University · USThe University of Texas Health Science Center at San Antonio · USNational Institutes of Health · US

Funding

Water Soluble Antimitotics That Circumvent Rumor ResistanceR01CA142868 · NCI · DUQUESNE UNIVERSITY · PI GANGJEE, ALEEM, MOOBERRY, SUSAN L · 2011 to 2015
$1.5M
NCI NIH HHS CA142868NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

A series of eleven 4-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-

Indexed as

Chemistry Techniques, SyntheticDrug DesignCell Line, TumorCell ProliferationDrug Resistance, NeoplasmHumansModels, MolecularMolecular ConformationMolecular StructureProtein MultimerizationPyrimidinesStructure-Activity RelationshipTubulinTubulin ModulatorsPyrimidinesTubulinTubulin Modulatorscolchicine siteGewald reactionmicrotubulesmicrotubule targeting agents

Identifiers

PMID35011550
PMCPMC8747035
OpenAlexW4205483630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.