Evidence map›Paper›PMID 35011496›Full record

ArticleMolecules (Basel, Switzerland)2022

Design, Synthesis and Preclinical Assessment of

Diana Trujillo-Benítez, Myrna Luna-Gutiérrez, Guillermina Ferro-Flores, Blanca Ocampo-García, Clara Santos-Cuevas, Gerardo Bravo-Villegas, Enrique Morales-Ávila, Pedro Cruz-Nova, Lorenza Díaz-Nieto, Janice García-Quiroz and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06753513 (Clinical Application of 99mTc-FDPH46 SPECT/CT Imaging in Malignant Solid Tumor), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06753513 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Clinical Application of 99mTc-FDPH46 SPECT/CT Imaging in Malignant Solid Tumor: a Prospective Exploratory Study

TypeobservationalSponsorZhejiang UniversityRan2024 to 2026Enrolled20ConditionsMalignant Tumors, Solid Tumor MalignancyArms99mTc-FDPH46 SPECT/CT Imaging
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Single Photon Emission Computed Tomography Tracer.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  2. Review
  3. New horizons in nuclear cardiology: Imaging of peripheral arterial disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. FAP-Targeted Nanoparticle-based Imaging in Cancer: A Systematic Review.Journal of biomedical physics & engineering · 2024
    Review
  8. EJNMMI radiopharmacy and chemistry · 2024
    Review
  9. Pharmaceutics · 2024
    Article
  10. Review
  11. Pharmaceutics · 2023
    Article
  12. Design, Synthesis, and Evaluation ofACS pharmacology & translational science · 2023
    Article
  13. Review
  14. Synthesis and Evaluation ofInternational journal of molecular sciences · 2023
    Article
  15. Synthesis and Preclinical Evaluation of NovelPharmaceuticals (Basel, Switzerland) · 2023
    Article
  16. NovelPharmaceuticals (Basel, Switzerland) · 2023
    Article
  17. A novel molecular imaging probe [Scientific reports · 2023
    Article
  18. Toxicity Assessment of [Nanomaterials (Basel, Switzerland) · 2022
    Article
  19. [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  20. [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Diana Trujillo-BenítezDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico.ORCID 0000-0002-0122-9355
Myrna Luna-GutiérrezDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico.
Guillermina Ferro-FloresDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico.ORCID 0000-0003-0296-7605
Blanca Ocampo-GarcíaDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico.ORCID 0000-0002-5831-8412
Clara Santos-CuevasDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico.
Gerardo Bravo-VillegasFaculty of Chemistry, Universidad Autónoma del Estado de México, Toluca 50180, Mexico.ORCID 0000-0003-4670-2908
Enrique Morales-ÁvilaFaculty of Chemistry, Universidad Autónoma del Estado de México, Toluca 50180, Mexico.ORCID 0000-0001-8471-6791
Pedro Cruz-NovaDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico.
Lorenza Díaz-NietoDepartment of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico.ORCID 0000-0002-5947-4222
Janice García-QuirozDepartment of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico.ORCID 0000-0002-3311-2258
Erika Azorín-VegaDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico.
Antonio RosatoDepartment of Surgery, Oncology and Gastroenterology, University of Padua, Via Gattamelata 64, 35138 Padua, Italy.ORCID 0000-0002-5263-8386
Laura Meléndez-AlafortDepartment of Immunology and Molecular Oncology Diagnostics, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35138 Padua, Italy.ORCID 0000-0003-0701-3616
Instituto Nacional de Investigaciones Nucleares · MXUniversidad Autónoma del Estado de México · MXInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXIstituto Oncologico Veneto · ITUniversity of Padua · IT

Funding

Consejo Nacional de Ciencia y Tecnología 314923
6 · The paper itself

Abstract

Fibroblast activation protein (FAP) is expressed in the microenvironment of most human epithelial tumors.

Indexed as

Liver Neoplasms, ExperimentalOrganotechnetium CompoundsRadiopharmaceuticalsSingle Photon Emission Computed Tomography Computed TomographyTechnetiumAnimalsEndopeptidasesFibroblast Activation Protein AlphaHep G2 CellsHumansMaleMembrane ProteinsMiceMice, Inbred BALB CNeoplasm ProteinsEndopeptidasesFibroblast Activation Protein AlphaMembrane ProteinsNeoplasm ProteinsOrganotechnetium CompoundsRadiopharmaceuticalsTechnetiumFAP inhibitorsfibroblast activation proteinHYNIC-iFAPtechnetium-99m

Identifiers

PMID35011496
PMCPMC8746441
OpenAlexW4205484087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.