ArticleMolecules (Basel, Switzerland)2021
Reduction of Deuterium Level Supports Resistance of Neurons to Glucose Deprivation and Hypoxia: Study in Cultures of Neurons and on Animals.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 22 citations in OpenAlex.
- Antioxidant and Anxiolytic Effects of Comenic Acid In Vivo and Cytoprotective Action In Vitro Against Manganese-Induced Neurotoxicity.Bulletin of experimental biology and medicine · 2026Article
- Transcriptomic Insights into Late-Life Depression and the Role of Environmental Drinking Water Composition: A Study on 18-Month-Old Mice.International journal of molecular sciences · 2025Article
- Altering the Hydrogen Isotopic Composition of the Essential Nutrient Water as a Promising Tool for Therapy: Perspectives and Risks.International journal of molecular sciences · 2025Review
- Effect of Deuterium Concentration in the Incubation Medium on Intracellular CaBulletin of experimental biology and medicine · 2025Article
- Effects of Deuterium Depletion on Age-Declining Thymopoiesis In Vivo.Biomedicines · 2024Article
- The biological impact of deuterium and therapeutic potential of deuterium-depleted water.Frontiers in pharmacology · 2024Review
- Structure and Neuroprotector Properties of a Complex Compound of Lithium with Comenic Acid.International journal of molecular sciences · 2023Article
- Influence of a Single Deuterium Substitution for Protium on the Frequency Generation of Different-Size Bubbles in IFNA17.International journal of molecular sciences · 2023Article
- Study of the Magnesium Comenate Structure, Its Neuroprotective and Stress-Protective Activity.International journal of molecular sciences · 2023Article
- Bilateral Shifts in Deuterium Supply Similarly Change Physiology of the Pituitary-Thyroid Axis, but Differentially Influence NaInternational journal of molecular sciences · 2023Article
- Changes in Secretion of the Thyroid and Pituitary Glands with a Gradual Decrease in Deuterium Body Content.Bulletin of experimental biology and medicine · 2023Article
- Emerging Role of Deuterium/Protium Disbalance in Cell Cycle and Apoptosis.International journal of molecular sciences · 2023Review
- Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range.International journal of molecular sciences · 2022Article
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9 authors at 4 institutions in 1 country.
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Abstract
The effect of a reduced deuterium (D) content in the incubation medium on the survival of cultured neurons in vitro and under glucose deprivation was studied. In addition, we studied the effect of a decrease in the deuterium content in the rat brain on oxidative processes in the nervous tissue, its antioxidant protection, and training of rats in the T-shaped maze test under hypoxic conditions. For experiments with cultures of neurons, 7-8-day cultures of cerebellar neurons were used. Determination of the rate of neuronal death in cultures was carried out using propidium iodide. Acute hypoxia with hypercapnia was simulated in rats by placing them in sealed vessels with a capacity of 1 L. The effect on oxidative processes in brain tissues was assessed by changes in the level of free radical oxidation and malondialdehyde. The effect on the antioxidant system of the brain was assessed by the activity of catalase. The study in the T-maze was carried out in accordance with the generally accepted methodology, the skill of alternating right-sided and left-sided loops on positive reinforcement was developed. This work has shown that a decrease in the deuterium content in the incubation medium to a level of -357‱ has a neuroprotective effect, increasing the survival rate of cultured neurons under glucose deprivation. When exposed to hypoxia, a preliminary decrease in the deuterium content in the rat brain to -261‱ prevents the development of oxidative stress in their nervous tissue and preserves the learning ability of animals in the T-shaped maze test at the level of the control group. A similar protective effect during the modification of the
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