Evidence map›Paper›PMID 35011245›Full record

ArticleMolecules (Basel, Switzerland)2021

Biophysical Evaluation and In Vitro Controlled Release of Two Isomeric Adamantane Phenylalkylamines with Antiproliferative/Anticancer and Analgesic Activity.

Marilena Vlachou, Angeliki-Sofia Foscolos, Angeliki Siamidi, Angeliki Syriopoulou, Nikitas Georgiou, Aikaterini Dedeloudi, Antonis D Tsiailanis, Andreas G Tzakos, Thomas Mavromoustakos, Ioannis P Papanastasiou

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marilena VlachouDivision of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 157 84 Athens, Greece.ORCID 0000-0002-2927-705X
Angeliki-Sofia FoscolosDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 157 84 Athens, Greece.
Angeliki SiamidiDivision of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 157 84 Athens, Greece.ORCID 0000-0002-8664-408X
Angeliki SyriopoulouDepartment of Organic Chemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece.
Nikitas GeorgiouDepartment of Organic Chemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece.
Aikaterini DedeloudiDivision of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 157 84 Athens, Greece.
Antonis D TsiailanisSection of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece.
Andreas G TzakosSection of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece.ORCID 0000-0001-6391-0288
Thomas MavromoustakosDepartment of Organic Chemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece.ORCID 0000-0001-5309-992X
Ioannis P PapanastasiouDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 157 84 Athens, Greece.ORCID 0000-0001-6974-2561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aqueous dissolution profile of the isomeric synthetic adamantane phenylalkylamine hydrochlorides

Indexed as

AdamantaneAnalgesicsAntineoplastic AgentsBiomechanical PhenomenaDelayed-Action PreparationsDrug CarriersDrug CompoundingDrug LiberationHumansHypromellose DerivativesIn Vitro TechniquesModels, ChemicalMolecular Dynamics SimulationStructure-Activity RelationshipAdamantaneAnalgesicsAntineoplastic AgentsDelayed-Action PreparationsDrug CarriersHypromellose Derivatives1D and 2D NMR spectroscopyadamantane phenylalkylaminescomputational analysiscontrolled release studiesenzymatic stability

Identifiers

PMID35011245
PMCPMC8746252

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.