Evidence map›Paper›PMID 35011220›Full record

ArticleAnimals : an open access journal from MDPI2022

MiR-22-3p Inhibits Proliferation and Promotes Differentiation of Skeletal Muscle Cells by Targeting IGFBP3 in Hu Sheep.

Shan Wang, Xiukai Cao, Ling Ge, Yifei Gu, Xiaoyang Lv, Tesfaye Getachew, Joram M Mwacharo, Aynalem Haile, Wei Sun

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  7. Pleiotropic GeneAnimals : an open access journal from MDPI · 2024
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shan WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Xiukai CaoJoint International Research Laboratory of Agriculture, Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-1846-8168
Ling GeCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Yifei GuCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Xiaoyang LvJoint International Research Laboratory of Agriculture, Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
Tesfaye GetachewInternational Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.
Joram M MwacharoInternational Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.
Aynalem HaileInternational Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.
Wei SunCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.

Funding

National Natural Science Foundation of China 31872333, 32172689National Natural Science Foundation of China-CGIAR 32061143036
6 · The paper itself

Abstract

The growth and development of skeletal muscle require a series of regulatory factors. MiRNA is a non-coding RNA with a length of about 22 nt, which can inhibit the expression of mRNA and plays an important role in the growth and development of muscle cells. The role of miR-22-3p in C2C12 cells and porcine skeletal muscle has been reported, but it has not been verified in Hu sheep skeletal muscle. Through qPCR, CCK-8, EdU and cell cycle studies, we found that overexpression of miR-22-3p inhibited proliferation of skeletal muscle cells (

Indexed as

differentiationHu sheepIGFBP3miR-22-3pproliferationskeletal muscle cells

Identifiers

PMID35011220
PMCPMC8749897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.