Evidence map›Paper›PMID 35011078›Full record

ArticleNutrients2022

Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI).

Michaela Härdrich, Anja Haase-Fielitz, Jens Fielitz, Michael Boschmann, Olga Pivovarova-Ramich, Andreas F H Pfeiffer, Natalia Rudovich, Karsten H Weylandt, Christian Butter

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Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Michaela HärdrichDepartment of Cardiology, Heart Centre Brandenburg Bernau, Faculty of Health Sciences Brandenburg, Brandenburg Medical School (MHB) Theodor Fontane, 16321 Bernau, Germany.
Anja Haase-FielitzDepartment of Cardiology, Heart Centre Brandenburg Bernau, Faculty of Health Sciences Brandenburg, Brandenburg Medical School (MHB) Theodor Fontane, 16321 Bernau, Germany.ORCID 0000-0001-6881-2249
Jens FielitzDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, 17489 Greifswald, Germany.ORCID 0000-0001-8522-1045
Michael BoschmannExperimental & Clinical Research Centre (ECRC), a Joint Cooperation between Charité-University Medicine Berlin and Max Delbrück Centre (MDC) for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Olga Pivovarova-RamichResearch Group Molecular Nutritional Medicine, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.ORCID 0000-0002-3583-8546
Andreas F H PfeifferDepartment Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.ORCID 0000-0002-6887-0016
Natalia RudovichDepartment of Internal Medicine, Spital STS AG, University of Zurich, 8006 Zurich, Switzerland.
Karsten H WeylandtMedical Department, Divisions of Hepatology, Gastroenterology, Oncology, Haematology, Palliative Care, Endocrinology and Diabetes, Ruppiner Kliniken, Brandenburg Medical School, 16816 Neuruppin, Germany.ORCID 0000-0002-5361-4327
Christian ButterDepartment of Cardiology, Heart Centre Brandenburg Bernau, Faculty of Health Sciences Brandenburg, Brandenburg Medical School (MHB) Theodor Fontane, 16321 Bernau, Germany.

Funding

The Brandenburg Ministry of Sciences, Research and Cultural Affairs. NA
6 · The paper itself

Abstract

backgroundMen and women with valvular heart disease have different risk profiles for clinical endpoints. Non-esterified fatty acids (NEFA) are possibly involved in cardio-metabolic disease. However, it is unclear whether NEFA concentrations are associated with physical performance in patients undergoing transcatheter aortic valve implantation (TAVI) and whether there are sex-specific effects.

methodsTo test the hypothesis that NEFA concentration is associated with sex-specific physical performance, we prospectively analysed data from one hundred adult patients undergoing TAVI. NEFA concentrations, physical performance and anthropometric parameters were measured before and 6 and 12 months after TAVI. Physical performance was determined by a six-minute walking test (6-MWT) and self-reported weekly bicycle riding time.

resultsBefore TAVI, NEFA concentrations were higher in patients (44 women, 56 men) compared to the normal population. Median NEFA concentrations at 6 and 12 months after TAVI were within the reference range reported in the normal population in men but not women. Men but not women presented with an increased performance in the 6-MWT over time (

conclusionsNEFA concentrations improved into the reference range in men but not women after TAVI. Men but not women have an increased physical performance after TAVI. No association between NEFA and physical performance was observed in men and women after TAVI.

Indexed as

Physical Functional PerformanceTranscatheter Aortic Valve ReplacementAgedAged, 80 and overAortic Valve StenosisBicyclingBiomarkersBody Mass IndexFatty Acids, NonesterifiedFemaleHumansMaleProspective StudiesReference ValuesRisk FactorsSex FactorsBiomarkersFatty Acids, Nonesterifiedbody compositionchronic kidney diseasecoronary heart diseasediabetes mellitusheart failuresex-specific differencessix-minute walking test (6-MWT)

Identifiers

PMID35011078
PMCPMC8747609

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.