Evidence map›Paper›PMID 35011069›Full record

ArticleNutrients2021

Nutritional Factors Associated with Late-Onset Sepsis in Very Low Birth Weight Newborns.

Juliany Caroline Silva de Sousa, Ana Verônica Dantas de Carvalho, Lorena de Carvalho Monte de Prada, Arthur Pedro Marinho, Kerolaynne Fonseca de Lima, Suianny Karla de Oliveira Macedo, Camila Dayze Pereira Santos, Saionara Maria Aires da Câmara, Anna Christina do Nascimento Granjeiro Barreto, Silvana Alves Pereira

Abstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Elimination ofAntibiotics (Basel, Switzerland) · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juliany Caroline Silva de SousaNeonatal Intensive Care Unit, Maternidade Escola Januário Cicco, Universidade Federal do Rio Grande do Norte, Natal 59012-300, Brazil.ORCID 0000-0002-2846-1568
Ana Verônica Dantas de CarvalhoNeonatal Intensive Care Unit, Maternidade Escola Januário Cicco, Universidade Federal do Rio Grande do Norte, Natal 59012-300, Brazil.
Lorena de Carvalho Monte de PradaNeonatal Intensive Care Unit, Maternidade Escola Januário Cicco, Universidade Federal do Rio Grande do Norte, Natal 59012-300, Brazil.ORCID 0000-0001-7746-5840
Arthur Pedro MarinhoNeonatal Intensive Care Unit, Maternidade Escola Januário Cicco, Universidade Federal do Rio Grande do Norte, Natal 59012-300, Brazil.
Kerolaynne Fonseca de LimaNeonatal Intensive Care Unit, Maternidade Escola Januário Cicco, Universidade Federal do Rio Grande do Norte, Natal 59012-300, Brazil.
Suianny Karla de Oliveira MacedoNeonatal Intensive Care Unit, Maternidade Escola Januário Cicco, Universidade Federal do Rio Grande do Norte, Natal 59012-300, Brazil.
Camila Dayze Pereira SantosNeonatal Intensive Care Unit, Maternidade Escola Januário Cicco, Universidade Federal do Rio Grande do Norte, Natal 59012-300, Brazil.ORCID 0000-0001-8092-2846
Saionara Maria Aires da CâmaraDepartment of Physiotherapy, Universidade Federal do Rio Grande do Norte, Natal 59075-000, Brazil.
Anna Christina do Nascimento Granjeiro BarretoNeonatal Intensive Care Unit, Maternidade Escola Januário Cicco, Universidade Federal do Rio Grande do Norte, Natal 59012-300, Brazil.ORCID 0000-0001-7319-5011
Silvana Alves PereiraNeonatal Intensive Care Unit, Maternidade Escola Januário Cicco, Universidade Federal do Rio Grande do Norte, Natal 59012-300, Brazil.ORCID 0000-0002-6226-2837

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelayed onset of minimal enteral nutrition compromises the immune response of preterm infants, increasing the risk of colonization and clinical complications (e.g., late-onset sepsis). This study aimed to analyze associations between late-onset sepsis in very low birth weight infants (<1500 g) and days of parenteral nutrition, days to reach full enteral nutrition, and maternal and nutritional factors.

methodsA cross-sectional study was carried out with very low birth weight infants admitted to a neonatal intensive care unit (NICU) of a reference maternity hospital of high-risk deliveries. Data regarding days of parenteral nutrition, days to reach full enteral nutrition, fasting days, extrauterine growth restriction, and NICU length of stay were extracted from online medical records. Late-onset sepsis was diagnosed (clinical or laboratory) after 48 h of life. Chi-squared, Mann-Whitney tests, and binary logistic regression were applied.

resultsA total of 97 preterm infants were included. Of those, 75 presented late-onset sepsis with clinical (

conclusionVery low birth weight infants with late-onset sepsis had prolonged parenteral nutrition and took longer to reach full enteral nutrition. They also presented a higher prevalence of extrauterine growth restriction than infants without late-onset sepsis.

Indexed as

Birth WeightCross-Sectional StudiesEnteral NutritionGastrointestinal TractGestational AgeHumansInfant, NewbornInfant Nutritional Physiological PhenomenaInfant, PrematureInfant, Very Low Birth WeightIntensive Care, NeonatalNeonatal SepsisParenteral NutritionTime Factorsenteral nutritionneonatal intensive care unitsneonatal sepsisparenteral nutritionpreterm infant

Identifiers

PMID35011069
PMCPMC8747100

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.