Evidence map›Paper›PMID 35011059›Full record

Trial reportNutrients2021

Nutritional Status Predicts Fatty Acid Uptake from Fish and Soybean Oil Supplements for Treatment of Cancer-Related Fatigue: Results from a Phase II Nationwide Study.

Amber S Kleckner, Eva Culakova, Ian R Kleckner, Elizabeth K Belcher, Wendy Demark-Wahnefried, Elizabeth A Parker, Gilbert D A Padula, Mary Ontko, Michelle C Janelsins, Karen M Mustian and 1 more

Open access · goldAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Amber S KlecknerDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD 21201, USA.ORCID 0000-0002-5088-1139
Eva CulakovaDepartment of Surgery, Division of Supportive Care in Cancer, University of Rochester Medical Center, Rochester, NY 14642, USA.
Ian R KlecknerDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
Elizabeth K BelcherDepartment of Psychological Science, Hobart and William Smith Colleges, Geneva, NY 14456, USA.
Wendy Demark-WahnefriedDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0001-5241-932X
Elizabeth A ParkerDepartment of Physical Therapy and Rehabilitation Science, School of Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
Gilbert D A PadulaDepartment of Radiation Oncology, University Hospitals St. John Medical Center, Westlake, OH 44145, USA.
Mary OntkoDayton Clinical Oncology Program, Dayton, OH 45420, USA.
Michelle C JanelsinsDepartment of Surgery, Division of Supportive Care in Cancer, University of Rochester Medical Center, Rochester, NY 14642, USA.
Karen M MustianDepartment of Surgery, Division of Supportive Care in Cancer, University of Rochester Medical Center, Rochester, NY 14642, USA.
Luke J PepponeDepartment of Surgery, Division of Supportive Care in Cancer, University of Rochester Medical Center, Rochester, NY 14642, USA.
University of Rochester Medical Center · USUniversity of Maryland, Baltimore · USDayton Clinical Oncology Program · USHobart and William Smith Colleges · USSt. John Medical Center · USUniversity of Alabama at Birmingham · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
Clinical and Translational Cancer Control Research Training ProgramT32CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, Gary R Morrow · 2019 to 2026
$2.7M
The Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy, Inflammation, and Interoceptive Brain CircuitryK07CA221931 · NCI · UNIVERSITY OF ROCHESTER · PI KLECKNER, IAN ROBERT · 2018 to 2022
$795k
Feasibility of Omega-3 Supplementation for Cancer-related FatigueR03CA175599 · NCI · UNIVERSITY OF ROCHESTER · PI PEPPONE, LUKE JOSEPH · 2014 to 2015
$154k
American Cancer Society CRP-19-175-06-COUNMaryland Department of Health's Cigarette Restitution Fund Program N/ANCI NIH HHS K07CA221931NCI NIH HHS P30CA134274NCI NIH HHS R03CA175599NCI NIH HHS T32CA102618NCI NIH HHS UG1 CA189961NCI NIH HHS UG1CA189961
6 · The paper itself

Abstract

Cancer-related fatigue is a prevalent and debilitating condition that persists for years into survivorship. Studies evaluating both fish oil supplementation on fatigue and associations between fish oil consumption and fatigue have shown mixed effects; it is unknown what factors contribute to these differential effects. Herein, we investigate whether the nutritional status of cancer survivors was associated with serum omega-3 concentration or change in serum omega-3s throughout a fish oil supplementation study, and then if any of these factors were associated with fatigue. Breast cancer survivors 4-36 months post-treatment with moderate-severe fatigue were randomized to take 6 g fish oil, 6 g soybean oil, or 3 g of each daily for 6 weeks. Baseline nutritional status was calculated using the Controlling Nutritional Status tool (serum albumin, lymphocytes, cholesterol). At baseline and post-intervention, serum fatty acids were quantified and fatigue was assessed using the Multidimensional Fatigue Symptom Inventory. Participants (

Indexed as

AgedBody Mass IndexBreast NeoplasmsDietary SupplementsFatigueFatty AcidsFatty Acids, Omega-3FemaleFish OilsHumansMiddle AgedNutritional StatusSoybean OilFatty AcidsFatty Acids, Omega-3Fish OilsSoybean Oilbreast cancerfish oilmalnutritionnutritional statusomega-3survivorship

Identifiers

PMID35011059
PMCPMC8747418
OpenAlexW4205794693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.