Evidence map›Paper›PMID 35011052›Full record

ArticleNutrients2021

Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury.

Myrna J V Brandt, Cora H Nijboer, Isabell Nessel, Tatenda R Mutshiya, Adina T Michael-Titus, Danielle S Counotte, Lidewij Schipper, Niek E van der Aa, Manon J N L Benders, Caroline G M de Theije

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Dietary LPC-BoundNutrients · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Myrna J V BrandtDepartment for Developmental Origins of Disease, University Medical Center Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, 3508 AB Utrecht, The Netherlands.ORCID 0000-0002-2529-5066
Cora H NijboerDepartment for Developmental Origins of Disease, University Medical Center Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, 3508 AB Utrecht, The Netherlands.
Isabell NesselCentre for Neuroscience, Surgery and Trauma, Blizard Institute, Queen Mary University of London, London E1 2AD, UK.ORCID 0000-0001-6621-4149
Tatenda R MutshiyaCentre for Neuroscience, Surgery and Trauma, Blizard Institute, Queen Mary University of London, London E1 2AD, UK.
Adina T Michael-TitusCentre for Neuroscience, Surgery and Trauma, Blizard Institute, Queen Mary University of London, London E1 2AD, UK.
Danielle S CounotteDanone Nutricia Research, 3508 TC Utrecht, The Netherlands.
Lidewij SchipperDanone Nutricia Research, 3508 TC Utrecht, The Netherlands.
Niek E van der AaDepartment of Neonatology, University Medical Center Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, 3508 AB Utrecht, The Netherlands.
Manon J N L BendersDepartment of Neonatology, University Medical Center Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, 3508 AB Utrecht, The Netherlands.ORCID 0000-0001-5491-9168
Caroline G M de TheijeDepartment for Developmental Origins of Disease, University Medical Center Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, 3508 AB Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perinatal hypoxia-ischemia (HI) is a major cause of neonatal brain injury, leading to long-term neurological impairments. Medical nutrition can be rapidly implemented in the clinic, making it a viable intervention to improve neurodevelopment after injury. The omega-3 (

Indexed as

Dietary SupplementsAnimalsBrainCholineDisease Models, AnimalDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3FemaleHumansHypoxia-Ischemia, BrainMaleMiceMice, Inbred C57BLNeuroinflammatory DiseasesSex CharacteristicsCholineDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Uridine MonophosphatecholineDHAdietEPAfish oilhypoxic-ischemic encephalopathyiodidemouseneonateneurodevelopmentneuroinflammationUMPvitamin B12zinc

Identifiers

PMID35011052
PMCPMC8747710

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.