Evidence map›Paper›PMID 35011034›Full record

ArticleNutrients2021

Total Fatty Acid and Polar Lipid Species Composition of Human Milk.

Talat Bashir Ahmed, Merete Eggesbø, Rachel Criswell, Olaf Uhl, Hans Demmelmair, Berthold Koletzko

Abstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Milk Fat Globules: 2024 Updates.Newborn (Clarksville, Md.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Talat Bashir AhmedDivision of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, LMU Klinikum, Ludwig-Maximilians-Universität, 80337 Munich, Germany.
Merete EggesbøDepartment of Environmental Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, 0213 Oslo, Norway.
Rachel CriswellDepartment of Environmental Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, 0213 Oslo, Norway.
Olaf UhlDivision of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, LMU Klinikum, Ludwig-Maximilians-Universität, 80337 Munich, Germany.
Hans DemmelmairDivision of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, LMU Klinikum, Ludwig-Maximilians-Universität, 80337 Munich, Germany.ORCID 0000-0001-7812-5178
Berthold KoletzkoDivision of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, LMU Klinikum, Ludwig-Maximilians-Universität, 80337 Munich, Germany.ORCID 0000-0002-5345-7165

Funding

Deutsche Forschungsgemeinschaft Ko912/12-1 and INST 409/224-1 FUGGEuropean Commission FP7 Programme Early Nutrition-289346European Commission H2020 Programmes DYNAHEALTH- 633595 und Lifecycle-733206European Research Council Advanced Grant META-GROWTH ERC-2012-AdG-no. 322605German Ministry of Education and Research Grant No. 01 GI 0825
6 · The paper itself

Abstract

Human milk lipids are essential for infant health. However, little is known about the relationship between total milk fatty acid (FA) composition and polar lipid species composition. Therefore, we aimed to characterize the relationship between the FA and polar lipid species composition in human milk, with a focus on differences between milk with higher or lower milk fat content. From the Norwegian Human Milk Study (HUMIS, 2002-2009), a subset of 664 milk samples were analyzed for FA and polar lipid composition. Milk samples did not differ in major FA, phosphatidylcholine, or sphingomyelin species percentages between the highest and lowest quartiles of total FA concentration. However, milk in the highest FA quartile had a lower phospholipid-to-total-FA ratio and a lower sphingomyelin-to-phosphatidylcholine ratio than the lowest quartile. The only FAs associated with total phosphatidylcholine or sphingomyelin were behenic and tridecanoic acids, respectively. Milk FA and phosphatidylcholine and sphingomyelin species containing these FAs showed modest correlations. Associations of arachidonic and docosahexaenoic acids with percentages of phosphatidylcholine species carrying these FAs support the conclusion that the availability of these FAs limits the synthesis of phospholipid species containing them.

Indexed as

Arachidonic AcidDocosahexaenoic AcidsFatty AcidsFemaleHumansLipidsMilk, HumanPhosphatidylcholinesPhospholipidsSphingomyelinsArachidonic AcidDocosahexaenoic AcidsFatty AcidsLipidsPhosphatidylcholinesPhospholipidsSphingomyelinsarachidonic aciddocosahexaenoic acidfat contentfatty acid compositionhuman milkphosphatidylcholinephospholipidssphingomyelin

Identifiers

PMID35011034
PMCPMC8747362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.